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WorksheetsToxicology Quiz
Total questions: 20
Worksheet time: 10mins
What is Toxicology?
The study of drugs only
The science of poisons
The study of infectious diseases
The study of vitamins
Toxicity is best defined as:
The speed of drug absorption
The ability of a substance to dissolve in water
The degree to which a substance can cause harm
The half-life of a chemical
Which factor does NOT affect toxicity?
Dose
Duration of exposure
Route of exposure
Color of the substance
Toxicokinetics is mainly concerned with:
What the toxicant does to the body
Toxic effects at the cellular level
What the body does to the toxicant
Binding of toxicants to receptors
Which of the following processes is NOT part of ADME?
Absorption
Distribution
Receptor binding
Metabolism
Which two processes are combined under the term “Elimination”?
Absorption and distribution
Metabolism and excretion
Absorption and metabolism
Distribution and excretion
Toxicodynamics focuses on:
Plasma concentration of a drug
Drug excretion
Toxic effects at the target site
Drug absorption mechanisms
Which statement best describes the relationship between absorption and toxicity?
Poorly absorbed substances are always toxic
Highly toxic substances must cause severe toxicity
Poor absorption may reduce toxicity
Absorption has no effect on toxicity
Which factor generally reduces toxicity?
Slow excretion
Storage in tissues
Rapid excretion
Formation of toxic metabolites
Biotransformation of a substance may result in:
Always reducing toxicity
Always increasing toxicity
Formation of more or less toxic metabolites
No change in toxicity
Bioavailability refers to:
The speed of drug absorption
The fraction of the administered dose reaching systemic circulation unchanged
The total amount of drug excreted
The half-life of a drug
Which transport mechanism does NOT require energy?
Active transport
Pinocytosis
Passive diffusion
Phagocytosis
Passive diffusion depends mainly on:
ATP consumption
Concentration gradient
Carrier proteins
Vesicle formation
Which organ is mainly responsible for drug metabolism?
Kidney
Lung
Liver
Brain
Which particle size is most likely to reach the alveoli in pulmonary absorption?
Greater than 5 microns
2–5 microns
Less than 1 micron
Greater than 10 microns
Which factor affects gastrointestinal absorption?
Blood flow to the site
Presence of food
pH of the environment
All of the above
Highly lipid-soluble substances are more likely to:
Remain in plasma
Be excreted rapidly
Cross cell membranes easily
Be poorly absorbed
Which statement about elimination is correct?
Faster elimination increases toxicity
Slower elimination reduces toxicity
Faster elimination usually reduces toxicity
Elimination has no effect on toxicity
Toxicokinetic data are often obtained by measuring:
Blood pressure
Plasma concentration over time
Body temperature
Heart rate
Which route of exposure involves absorption through the lungs?
Ingestion
Inhalation
Dermal contact
Injection
