WorksheetsMajor Histocompatibility Complex Quiz
Total questions: 23
Worksheet time: 12mins
Major Histocompatibility Complex (MHC) in humans is called
H-2 system
ABO system
HLA system
Rh system
MHC Class I molecules are expressed on
Only antigen presenting cells
All nucleated cells
RBCs only
B lymphocytes only
MHC Class II molecules are expressed mainly on
All cells
Neutrophils only
Professional APCs
RBCs
MHC Class I presents antigen to
CD4 T cells
CD8 T cells
B cells
NK cells
MHC Class II presents antigen to
CD8 T cells
CD4 T cells
NK cells
Plasma cells
Central tolerance primarily occurs in
Peripheral tissues
Thymus and bone marrow
Spleen
Lymph nodes
Peripheral tolerance includes all EXCEPT
Anergy
Deletion
Regulatory T cells
Somatic hypermutation
Anergy refers to
Cell activation without antigen
Functional inactivation of lymphocytes
Cell death
Antibody production
Autoimmunity is defined as
Immune response against microbes only
Loss of immune tolerance to self antigens
Immunodeficiency state
Allergic response
Type II hypersensitivity mechanism is commonly involved in
Graves disease
Systemic lupus erythematosus
Contact dermatitis
Serum sickness
Immune complex mediated autoimmune disease is
Systemic lupus erythematosus
Myasthenia gravis
Hashimoto thyroiditis
Type 1 diabetes
Organ-specific autoimmune disease is
RA
SLE
Type 1 diabetes
Polyarteritis nodosa
Systemic autoimmune disease is
Myasthenia gravis
Hashimoto thyroiditis
Systemic lupus erythematosus
Pernicious anemia
Severe Combined Immunodeficiency (SCID) involves defect in
B cells only
T cells only
Both B and T cells
Complement system
Common cause of X-linked SCID is deficiency of
ADA
Common gamma chain
CD3
C3
ADA deficiency leads to
SCID
CGD
DiGeorge syndrome
Wiskott-Aldrich syndrome
Immunodeficiency due to defective phagocytosis is seen in
SCID
Chronic granulomatous disease
Bruton agammaglobulinemia
Selective IgA deficiency
CGD is due to defect in
NADPH oxidase
Myeloperoxidase
Complement C3
ADA
Graft-versus-host disease occurs when
Host attacks graft
Donor T cells attack host tissues
Antibodies destroy graft
Graft is rejected
Common target organs in GVHD include
Skin liver and GIT
Heart lungs brain
Kidney spleen pancreas
Bone marrow only
Tumor antigens are best described as
Self antigens only
Antigens expressed by tumor cells
Only viral antigens
Only differentiation antigens
Tumor-associated differentiation antigen example is
HER2/neu
AFP
Melan-A
CEA
Oncofetal tumor antigen includes
PSA
AFP
HER2/neu
KRAS
