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Liver Function and Disorders Quiz

Total questions: 40

Worksheet time: 20mins

Name
Class
Date
1.

The functional unit of the liver is the:

a)

Hepatocyte

b)

Sinusoid

c)

Lobule

d)

Portal triad

2.

Which blood vessel supplies nutrient-rich blood to the liver?

a)

Hepatic artery

b)

Hepatic vein

c)

Portal vein

d)

Inferior vena cava

3.

Kupffer cells primarily function to:

a)

Produce bile

b)

Store glycogen

c)

Perform phagocytosis

d)

Conjugate bilirubin

4.

Unconjugated bilirubin is:

a)

Water-soluble

b)

Bound to albumin

c)

Excreted in urine

d)

Found in bile

5.

The enzyme responsible for bilirubin conjugation is:

a)

ALT

b)

AST

c)

UDP-glucuronosyltransferase

d)

Alkaline phosphatase

6.

Conjugated bilirubin is best described as:

a)

Lipid-soluble

b)

Albumin-bound

c)

Water-soluble

d)

Found only in blood

7.

The brown color of stool is due to:

a)

Urobilin

b)

Bilirubin

c)

Stercobilin

d)

Hemoglobin

8.

Which condition causes unconjugated hyperbilirubinemia?

a)

Dubin–Johnson syndrome

b)

Rotor syndrome

c)

Gilbert’s syndrome

d)

Biliary obstruction

9.

Prehepatic jaundice is commonly caused by:

a)

Gallstones

b)

Hemolysis

c)

Hepatitis

d)

Cirrhosis

10.

Clay-colored stool is seen in:

a)

Prehepatic jaundice

b)

Hepatic jaundice

c)

Posthepatic jaundice

d)

Gilbert’s syndrome

11.

Which enzyme is most specific for liver injury?

a)

AST

b)

ALT

c)

ALP

d)

CK

12.

Elevated ALP and GGT suggest:

a)

Muscle damage

b)

Hemolysis

c)

Biliary obstruction

d)

Renal failure

13.

Albumin reflects the liver’s:

a)

Excretory function

b)

Detoxification

c)

Synthetic function

d)

Immune response

14.

A prolonged PT indicates impaired:

a)

Protein digestion

b)

Clotting factor synthesis

c)

Bile secretion

d)

Ammonia excretion

15.

The most common cause of cirrhosis in the US is:

a)

Viral hepatitis

b)

Alcoholism

c)

Autoimmune disease

d)

Cancer

16.

Hepatocellular carcinoma usually develops in patients with:

a)

Healthy liver

b)

Acute infection

c)

Cirrhosis

d)

Gallstones

17.

Reye’s syndrome is associated with:

a)

Antibiotic use

b)

Aspirin use in children

c)

Alcohol intake

d)

Smoking

18.

Which virus is most strongly linked to liver cancer?

a)

HAV

b)

HBV

c)

HIV

d)

EBV

19.

AST/ALT ratio >2 suggests:

a)

Viral hepatitis

b)

Alcoholic liver disease

c)

Muscle injury

d)

Hemolysis

20.

The primary site of drug metabolism is:

a)

Kidney

b)

Lungs

c)

Liver

d)

Intestines

21.

CYP450 enzymes are involved in drug:

a)

Absorption

b)

Excretion

c)

Detoxification

d)

Storage

22.

Delta bilirubin is:

a)

Unconjugated bilirubin

b)

Free bilirubin

c)

Albumin-bound conjugated bilirubin

d)

Urobilinogen

23.

Dubin–Johnson syndrome causes:

a)

Unconjugated bilirubin increase

b)

Conjugated bilirubin increase

c)

Normal bilirubin

d)

Hemolysis

24.

Which is NOT synthesized by the liver?

a)

Albumin

b)

Clotting factors

c)

Immunoglobulins

d)

Acute-phase proteins

25.

The liver stores all EXCEPT:

a)

Glycogen

b)

Vitamin A

c)

Iron

d)

Vitamin C

26.

Elevated ammonia is seen in:

a)

Kidney disease

b)

Liver failure

c)

Lung disease

d)

Heart failure

27.

Urobilinogen is formed in the:

a)

Liver

b)

Blood

c)

Intestines

d)

Kidney

28.

The yellow discoloration of serum is called:

a)

Jaundice

b)

Icterus

c)

Cholestasis

d)

Hepatitis

29.

Which test best assesses hepatocellular injury?

a)

ALP

b)

GGT

c)

ALT

d)

Bilirubin

30.

Which condition is benign?

a)

Crigler–Najjar type I

b)

Hepatocellular carcinoma

c)

Gilbert’s syndrome

d)

Cirrhosis

31.

Bile is secreted into the:

a)

Portal vein

b)

Hepatic artery

c)

Bile canaliculi

d)

Central vein

32.

Stercobilin is excreted in:

a)

Urine

b)

Sweat

c)

Feces

d)

Blood

33.

Which causes posthepatic jaundice?

a)

Hemolysis

b)

Hepatitis

c)

Gallstones

d)

Gilbert’s syndrome

34.

The liver receives ~75% of its blood from:

a)

Hepatic artery

b)

Hepatic vein

c)

Portal vein

d)

Aorta

35.

Which lab result indicates cholestasis?

a)

↑ ALT

b)

↑ AST

c)

↑ ALP

d)

↓ Albumin

36.

The main bile pigment is:

a)

Hemoglobin

b)

Bilirubin

c)

Urobilin

d)

Iron

37.

Hepatic encephalopathy is related to:

a)

High glucose

b)

High ammonia

c)

Low bilirubin

d)

Low cholesterol

38.

Which disorder presents with dark liver pigmentation?

a)

Gilbert’s

b)

Rotor

c)

Dubin–Johnson

d)

Crigler–Najjar

39.

The life span of RBCs is about:

a)

60 days

b)

90 days

c)

120 days

d)

150 days

40.

Which test reflects long-term liver damage?

a)

ALT

b)

AST

c)

Albumin

d)

ALP