WorksheetsBMZ and Immune System in normal and AIBD skin
Total questions: 10
Worksheet time: 8mins
What key structural feature of the hemidesmosome interacts with intermediate filaments of cells?
The lamina densa
The inner layer
The outer layer communicating with transmembrane proteins
The anchoring filaments
What are the two domains of type IV collagen that are key to the formation of the collagen network?
The NC1 domain and the 7S domain
The NC1 domain and the triple helical domain
The triple helical domain and the 7S domain
The N-terminal domain and the triple helical domain
What is the specific domain of type XVII collagen (BP180) that IgG autoantibodies target in some forms of bullous pemphigoid?
The C-terminal collagen domain
The NC16A domain
The flexible tail region
The largest collagenous domain 15
The intracellular portion of type XVII collagen binds to which specific component of the hemidesmosome?
Type IV collagen
The α6 integrin
Laminin-332
The β4 integrin
What specific structural feature of type VII collagen monomers is hydroxylated using ascorbic acid as a cofactor for additional stability?
The cysteine residues
The prolines
The glycine residues
The lysine residues
What is the clinical consequence of IgG autoantibodies targeting the NC1 domain of type VII collagen?
Generalized atrophic benign epidermolysis bullosa (GABEB)
Bullous pemphigoid
Cicatricial pemphigoid
Epidermolysis bullosa acquisita
In recessive dystrophic epidermolysis bullosa (DEB), what genetic mechanism often results in the complete absence of anchoring fibrils?
Premature stop codons
Deletions in the NC16A domain
Mutations in the laminin-332 gene
Glycine substitutions in the central repeat region
According to the "desmoglein compensation theory", what determines the clinical phenotype (mucosal vs. mucocutaneous) in pemphigus vulgaris?
The presence of anti-Dsg1 IgG only
The presence of anti-Dsg3 IgG only or in combination with anti-Dsg1 IgG
The ratio of IgG4 to IgG1 antibodies
The involvement of CD4+ T cells
In bullous pemphigoid (BP), T cell and autoantibody reactivities to which specific region of the BP180 protein were related to more extensive disease activity?
The transmembrane domain
The cytoplasmic tail
NH2-terminal epitopes
The collagenous domain
Which immunoglobulin subclass autoantibodies are primarily found in pemphigoid gestationis patients and are noted as complement-fixing?
IgG2 and IgG4
IgG1 and IgG3
IgG1 and IgG4
IgG3 and IgG4
