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Neuromuscular Junction Quiz

Total questions: 20

Worksheet time: 10mins

Name
Class
Date
1.

Neuromuscular junction is a synapse between

a)

Two neurons

b)

Motor neuron and skeletal muscle

c)

Sensory neuron and muscle

d)

Autonomic neuron and smooth muscle

2.

Neurotransmitter released at NMJ is

a)

GABA

b)

Glutamate

c)

Acetylcholine

d)

Noradrenaline

3.

Type of receptor present at NMJ is

a)

Muscarinic

b)

Nicotinic Nm

c)

Alpha adrenergic

d)

Beta adrenergic

4.

Width of synaptic cleft at NMJ is about

a)

2 nm

b)

5 nm

c)

20–30 nm

d)

100 nm

5.

NMJ transmission is

a)

Electrical

b)

Chemical

c)

Both electrical and chemical

d)

Inhibitory

6.

Calcium is required at NMJ for

a)

Muscle contraction

b)

ACh synthesis

c)

ACh release

d)

Na⁺ influx

7.

End plate potential is due to influx of

a)

Calcium ions

b)

Potassium ions

c)

Sodium ions

d)

Chloride ions

8.

Enzyme present in synaptic cleft is

a)

Choline acetyltransferase

b)

Acetylcholinesterase

c)

Monoamine oxidase

d)

COMT

9.

Myasthenia gravis is caused by antibodies against

a)

ACh

b)

Nm receptors

c)

Muscle actin

d)

Calcium channels

10.

Characteristic feature of myasthenia gravis is

a)

Muscle rigidity

b)

Muscle wasting

c)

Fatigability of muscles

d)

Spastic paralysis

11.

Drug of choice for myasthenia gravis is

a)

Atropine

b)

Neostigmine

c)

Curare

d)

Adrenaline

12.

Curare acts by

a)

Blocking ACh release

b)

Blocking Nm receptors

c)

Inhibiting AChE

d)

Stimulating muscle fiber

13.

Botulinum toxin causes paralysis by

a)

Blocking ACh synthesis

b)

Blocking ACh release

c)

Destroying receptors

d)

Inhibiting AChE

14.

Acetylcholine is synthesized in nerve terminal from

a)

Choline + Acetate

b)

Choline + Acetyl CoA

c)

Acetate + CoA

d)

Choline alone

15.

Safety factor at NMJ refers to

a)

Amount of Ca²⁺ present

b)

Excess ACh released

c)

Width of synaptic cleft

d)

Number of receptors

16.

NMJ is always

a)

Inhibitory

b)

Excitatory

c)

Both

d)

Electrical

17.

Junctional folds are present on

a)

Presynaptic membrane

b)

Postsynaptic membrane

c)

Synaptic vesicles

d)

Axon hillock

18.

Hemicholinium blocks

a)

Choline uptake

b)

ACh release

c)

ACh receptors

d)

ACh breakdown

19.

Organophosphates act by

a)

Blocking receptors

b)

Inhibiting AChE

c)

Blocking Na⁺ channels

d)

Blocking Ca²⁺ channels

20.

Lambert-Eaton syndrome involves antibodies against

a)

ACh receptors

b)

Na⁺ channels

c)

Ca²⁺ channels on nerve terminal

d)

Muscle fibers