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MB221 (CMIR)

Total questions: 10

Worksheet time: 10mins

Name
Class
Date
1.

Which immune cells mediate cell-mediated immunity?

a)

B lymphocytes

B lymphocytes

b)

Macrophage

Macrophage

c)

APCs

APCs

d)

T lymphocytes

T lymphocytes

2.

2. Which cell is the most effective antigen-presenting cell (APC)?

a)

Neutrophil

Neutrophil

b)

Dendritic cell

Dendritic cell

c)

B cell

B cell

d)

Macrophage

Macrophage

3.

Reorder the following

a)

Dendritic cell captures and processes antigen

b)

Dendritic cell migrates to lymph node

c)

T cell recognizes peptide–MHC complex

d)

T cell proliferates and differentiates

1)
2)
3)
4)
4.

Match the following

Categorize the following

Expressed on all nucleated cells

Presents endogenous peptides

Recognized by CD8+ T cells

Expressed on APCs

Presents extracellular peptides

Recognized by CD4+ T cells

MHC class I
MHC class II
5.

Match the following

a)

Naïve T cell

1.

Has not encountered antigen

b)

Effector T cell

2.

Performs immediate immune function

c)

Memory T cell

3.

Long-lived, rapid response

6.

What are the key signaling components in Signal 1 and 2 ?

7.

6. Which cytokine promotes Th2 differentiation?

a)

IL-12

b)

IFN-γ

c)

IL-4

d)

IL-17

8.

Match cytokines with their major functions

a)

IFN-γ

1.

M1 Macrophage activation

b)

IL-5

2.

Eosinophil activation

c)

IL-17

3.

Neutrophil recruitment

d)

IL-4

4.

IgE mediated Allergy

9.

Which of the following best describes central tolerance?

a)

Deletion of autoreactive T cells in the thymus

b)

Suppression by Treg cells in tissues

c)

Lack of antigen exposure

d)

Antibody neutralization

10.

Arrange the steps of the T cell–mediated immune response in the correct order:

a)

Antigen recognition

b)

T lymphocyte activation

c)

Antigen elimination

d)

Contraction (homeostasis)

e)

Memory formation

1)
2)
3)
4)
5)