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WorksheetsPathology Quiz
Total questions: 10
Worksheet time: 5mins
A 62-year-old male dies 4 days after an acute myocardial infarction. At autopsy, the infarcted ventricular wall is soft, yellowish, and shows a rupture of the ventricular septum. Which histological feature is most characteristic of this specific time frame (Day 3–7)?
Wavy fibers and contraction band necrosis
Extensive macrophage infiltration and phagocytosis of dead myocytes
Dense collagenous scar formation
Early neutrophilic infiltration and coagulative necrosis
In 'Rheumatic Heart Disease,' the pathognomonic histological lesion found in the myocardium, consisting of a central focus of fibrinoid necrosis surrounded by Anitschkow cells, is known as:
Councilman body
Aschoff body
Negri body
Mallory-Denk body
A patient presents with hemoptysis and rapidly progressing renal failure. Immunofluorescence of a renal biopsy shows a 'linear' pattern of IgG deposition along the glomerular basement membrane. What is the most likely diagnosis?
Post-streptococcal glomerulonephritis
Goodpasture Syndrome
Wegener’s Granulomatosis
Minimal Change Disease
Which morphological subtype of lung carcinoma is most strongly associated with non-smokers and is characterized by a 'lepidic' growth pattern along intact alveolar septa?
Squamous cell carcinoma
Small cell carcinoma
Adenocarcinoma (formerly Bronchioloalveolar)
Large cell carcinoma
'Barrett’s Esophagus' is a pre-malignant condition defined by the metaplastic replacement of the normal esophageal epithelium with:
Stratified squamous epithelium
Simple columnar epithelium with goblet cells (Intestinal metaplasia)
Pseudostratified ciliated columnar epithelium
Transitional epithelium
A 'Crohn's Disease' biopsy reveals transmural inflammation. Which other feature would help distinguish it from Ulcerative Colitis?
Presence of non-caseating granulomas
Inflammation limited to the mucosa and submucosa
Continuous involvement starting from the rectum
Absence of 'Skip Lesions'
In the liver, the 'Councilman body' represents a single hepatocyte that has undergone:
Fatty change (Steatosis)
Liquefactive necrosis
Apoptosis (often seen in viral hepatitis)
Hypertrophy
Which form of 'Emphysema' is classically associated with Alpha-1 Antitrypsin deficiency and typically involves the entire acinus, predominantly in the lower lobes?
Centriacinar emphysema
Panacinar emphysema
Paraseptal emphysema
Irregular emphysema
'Membranous Nephropathy' is characterized by the presence of 'Spikes and Domes' on the glomerular basement membrane. These are visualized best using which stain?
Hematoxylin and Eosin (H&E)
Periodic Acid-Schiff (PAS)
Silver stain (Jones)
Congo Red
A 45-year-old female presents with itching, jaundice, and a positive anti-mitochondrial antibody (AMA) test. The pathology shows destruction of the small intrahepatic bile ducts. What is the diagnosis?
Primary Sclerosing Cholangitis
Primary Biliary Cholangitis (formerly Cirrhosis)
Alcoholic Hepatitis
Hemochromatosis
