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WorksheetsEndocrine and Neurophysiology Quiz
Total questions: 15
Worksheet time: 8mins
A patient with a pituitary tumor has high levels of serum cortisol. After receiving a high-dose dexamethasone suppression test, the cortisol levels drop by 50%. What is the most likely diagnosis?
Adrenal adenoma
Ectopic ACTH-producing tumor (e.g., small cell lung cancer)
Cushing’s Disease (Pituitary adenoma)
Primary adrenal insufficiency
Which of the following is the primary mechanism by which Insulin increases glucose uptake in skeletal muscle?
Activation of SGLT-2 transporters
Recruitment of GLUT-4 transporters to the plasma membrane
Phosphorylation of Hexokinase
Inhibition of Glucagon secretion
In the synthesis of Thyroid Hormones, which step is specifically inhibited by high levels of inorganic iodide (the Wolff-Chaikoff effect)?
Iodide trapping
Synthesis of Thyroglobulin
Organification of iodine
Proteolysis of T3 and T4
A patient presents with hypercalcemia and low serum phosphate. PTH levels are elevated. What is the expected finding in the urine?
Decreased cAMP
Increased Phosphate excretion
Decreased Calcium excretion
Increased Bicarbonate reabsorption
Which hormone acts via a cGMP-mediated second messenger system?
Epinephrine
Atrial Natriuretic Peptide (ANP)
Glucagon
Antidiuretic Hormone (V2 receptor)
During the menstrual cycle, what is the primary trigger for the 'LH Surge'?
Negative feedback of Progesterone
Positive feedback of High-level Estrogen
Pulsatile release of GnRH at low frequency
Inhibin B peak
In a male with a genetic mutation resulting in a lack of 5-alpha reductase, which of the following will be most significantly affected?
Development of internal male genitalia (Epididymis, Vas deferens)
Differentiation of external male genitalia
Production of Testosterone by Leydig cells
Descent of testes during puberty
Which cell type in the testes is responsible for the blood-testis barrier and secretes Androgen Binding Protein (ABP)?
Leydig cells
Spermatogonia
Sertoli cells
Myoid cells
What is the primary function of Human Chorionic Gonadotropin (hCG) during the first trimester of pregnancy?
To stimulate fetal lung maturity
To maintain the Corpus Luteum for progesterone production
To initiate uterine contractions
To inhibit Maternal Insulin secretion
Which hormone is primarily responsible for the 'ejection' (let-down) of milk during breastfeeding?
Prolactin
Estrogen
Oxytocin
Progesterone
During an action potential, the 'Absolute Refractory Period' is primarily due to:
Hyperpolarization by Potassium channels
Closure of the Activation gate of Sodium channels
Inactivation of the Inactivation gate of Sodium channels
Increased membrane resistance
A patient loses pain and temperature sensation on the left side of the body below the T10 level, but retains fine touch and proprioception. Where is the lesion?
Left dorsal column
Right lateral spinothalamic tract
Left lateral spinothalamic tract
Total spinal cord transection at T10
Which neurotransmitter is released by all pre-ganglionic autonomic fibers (both Sympathetic and Parasympathetic)?
Norepinephrine
Epinephrine
Acetylcholine
Dopamine
In the Phototransduction cascade in the retina, what happens to a rod cell when it is exposed to light?
It depolarizes due to Sodium influx
It hyperpolarizes due to a decrease in cGMP
It releases more Glutamate
Sodium channels open
Which part of the cerebellum is primarily responsible for planning and initiation of complex movements?
Vestibulocerebellum
Spinocerebellum
Cerebrocerebellum (Neocerebellum)
Flocculonodular lobe
