SF Week 5

Front

What is Porphyria cutanea tarda?

Back

A disorder characterized by cutaneous symptoms and photosensitivity, often associated with red to brown urine in natural light and pink to red in fluorescent light.

Front

What is the primary transport mechanism for unconjugated bilirubin in the blood?

Back

Unconjugated bilirubin is transported bound to albumin.

Front

What molecule is required to convert UMP to CTP?

Back

Glutamine is required to convert UMP to CTP.

Front

What is the product of the decarboxylation reaction in catecholamine synthesis?

Back

The product is dopamine, and the cofactor required is pyridoxal phosphate.

Front

What are the symptoms of Porphyria cutanea tarda?

Back

Symptoms include cutaneous lesions, photosensitivity, and discolored urine.

Front

What is the role of albumin in bilirubin transport?

Back

Albumin binds to unconjugated bilirubin, facilitating its transport in the bloodstream.

Front

What is the significance of glutamine in nucleotide synthesis?

Back

Glutamine provides nitrogen for the conversion of UMP to CTP, a crucial step in nucleotide metabolism.

Front

What cofactor is essential for the synthesis of dopamine from L-DOPA?

Back

Pyridoxal phosphate is the essential cofactor for the synthesis of dopamine.

Front

What are the clinical features of acute intermittent porphyria?

Back

Acute intermittent porphyria presents with abdominal pain, neurological symptoms, and psychiatric disturbances.

Front

How does lead poisoning affect heme synthesis?

Back

Lead poisoning inhibits enzymes in the heme synthesis pathway, leading to anemia and neurological symptoms.