Chapter 17: Statistical Methods Used in Interim Monitoring

Front

The aim of this group of methods is to minimize the # of participants that must be entered into a study. Options: Group Sequential Methods, Classical Sequential Methods, Alpha Spending, Repeated Significance Test

Back

Classical Sequential Methods

Front

____ has an advantage over ____ in that data do not have to be continuously tested

Back

Group Sequential Methods have an advantage over Classical Sequential Methods in that data do not have to be continuously tested.

Front

____ has an advantage over ____ in that individuals do not have to be paired

Back

Group Sequential Methods have an advantage over Classical Sequential Methods in that individuals do not have to be paired.

Front

This group of trials is better for acute diseases compared to chronic diseases: Alpha Spending, Classical Sequential Methods, Group Sequential Methods, Pocock's Method

Back

Classical Sequential Methods

Front

This group of methods isn't used very widely because of ethical concerns regarding too frequent analysis

Back

Classical Sequential Methods

Front

In this trial, data has to be paired with an observation from each group and there is no fixed sample size

Back

Open Plan

Front

In this trial, data has to be paired with an observation from each group and there is a fixed sample size

Back

Closed Sequential Design

Front

In an Open Plan, stratification can be used to make the pairings better but what problem does the book mention this could cause?

Back

One or more unpaired participants

Front

This Classical Sequential Method introduces criteria for early termination & rejection of no treatment effect, which in turn determines the level(s) of significance and power.

Back

Closed Sequential Design

Front

This test is similar to a Closed Sequential Design and was proposed as a possible solution to the repeated testing problem

Back

Repeated Significance Test