Pharmacology of Antibiotics

Front

What is the primary mechanism of antibacterial action of penicillins?

Back

Inhibition of peptidoglycan cross-linking.

Front

Which bacteria is cloxacillin effective against?

Back

Methicillin Sensitive Staphylococcus aureus (MSSA).

Front

What class of penicillin is commonly used against methicillin sensitive Staphylococcus aureus?

Back

Penicillinase-Resistant Penicillin.

Front

Are natural penicillins commonly used against Staphylococcus aureus?

Back

No.

Front

Which natural penicillin is administered parenterally?

Back

Penicillin G.

Front

What is the role of beta-lactamases in antibiotic resistance?

Back

Beta-lactamases are enzymes produced by bacteria that break down beta-lactam antibiotics, rendering them ineffective.

Front

What is the difference between natural penicillins and penicillinase-resistant penicillins?

Back

Natural penicillins are susceptible to beta-lactamases, while penicillinase-resistant penicillins are designed to resist these enzymes.

Front

What is the significance of peptidoglycan in bacterial cell walls?

Back

Peptidoglycan provides structural integrity to bacterial cell walls, making it a target for antibiotics.

Front

What type of bacteria is typically targeted by aminopenicillins?

Back

Aminopenicillins are effective against a broader spectrum of bacteria, including some Gram-negative bacteria.

Front

What is the mechanism of action of aminoglycosides?

Back

Aminoglycosides inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit.