Ph.Org.Chem. Pharm D chap 13

Front

What is the Hoffman rearrangement?

Back

A chemical reaction that involves the migration of an electron-deficient nitrogen.

Front

What is Sandmeyer’s reaction?

Back

A reaction used to synthesize aryl halides from aryl amines.

Front

What is the basicity of amines?

Back

Amines are basic due to the presence of a lone pair of electrons on the nitrogen atom.

Front

What is diazotisation?

Back

The process of converting primary amines into diazonium salts.

Front

What is coupling in the context of diazotisation?

Back

The reaction of diazonium salts with activated aromatic compounds to form azo compounds.

Front

What is the acidity of phenols?

Back

Phenols are weak acids due to the resonance stabilization of their phenoxide ions.

Front

What is Williamson synthesis?

Back

A method for synthesizing ethers by reacting an alkoxide ion with a primary alkyl halide.

Front

What is Fries rearrangement?

Back

A reaction that involves the rearrangement of aryl esters to ortho- and para-hydroxyaryl ketones.

Front

What is the Kolbe reaction?

Back

An electrochemical reaction that produces carboxylic acids from the electrolysis of sodium or potassium salts of carboxylic acids.

Front

What is Reimer-Tiemann reaction?

Back

A reaction that involves the ortho-formylation of phenols using chloroform and a strong base.