Genetic Analysis and Testing

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Reading Assignment for Chapter 7

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Linkage, Recombination and Eukaryotic Gene Mapping (pg. 173-216)

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Gene linkage definition

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Define gene linkage and distinguish between linked genes and sex-linked genes

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Define LOD score

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A statistical measure used to evaluate the likelihood of a particular genetic linkage.

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Define SNPs

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Single Nucleotide Polymorphisms, variations at a single position in a DNA sequence among individuals.

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Define linkage disequilibrium

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The non-random association of alleles at different loci.

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Unaffected person symbol for sex unknown or unspecified

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A diamond

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Person affected with trait symbol for male

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A filled square

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Obligate carrier symbol for sex unknown or unspecified

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A diamond with a dot inside

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Asymptomatic carrier symbol for male

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A square with a vertical line

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Asymptomatic carrier symbol for sex unknown or unspecified

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A diamond with a vertical line