initiation proteins involved in eukaryotic translation

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eIF2

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primarily responsible for bringing the initiator Met-tRNA to the 40s subunit of the ribosome

Front

Poly-A binding protein (PABP)

Back

binds to the 3;' end of the poly A tail and interacts with eIF4G which circularizes the mRNA, therefore enhancing tranlsational efficiency

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43S pre-initiation complex

Back

eIF1, eIF1A, eIF2-GTP, eIF3

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Internal ribosome entry site (IRES)

Back

allows for translation initiation without the 5' cap in certain eukaryotes

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Kozak sequence

Back

a sequence that surrounds the start sequence for translation in eukaryotes. The 40s subunit scans along the mRNA until it reaches this sequence

Front

eIF1A

Back

helps separate the large subunit from the small subunit of the ribosome; it binds into the A site

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eIF3

Back

helps separate the large subunit from the small subunit of the ribosome (in general)

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eIF1

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bings into the E site before translation begins to prevent tRNAs with amino acids to bind into that site.

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eIF4E

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the cap binding protein and is also a part of the eIF4F complex

Front

eIF4B

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activates the RNA helices to unwind any secondary structures that may have formed in the mRNA