Penicillin and Related Antibiotics Flashcard

Front

What is the mechanism of resistance for Penicillins?

Back

Drug inactivation by beta-lactamase production.

Front

Which bacteria are targeted by Ciprofloxacin?

Back

Klebsiella, P. aeruginosa.

Front

What is the mechanism of action of Daptomycin?

Back

Binds cytoplasmic membrane causing depolarization.

Front

Which bacteria are resistant to Penicillin's due to drug inactivation by beta-lactamase production?

Back

MRSA.

Front

What is the MOA of fluoroquinolones?

Back

Inhibit DNA topoisomerase II and IV.

Front

What is beta-lactamase?

Back

An enzyme produced by bacteria that inactivates beta-lactam antibiotics.

Front

What is the primary action of Penicillins?

Back

Inhibit bacterial cell wall synthesis.

Front

What type of bacteria is Daptomycin effective against?

Back

Gram-positive bacteria.

Front

What is the role of efflux pumps in antibiotic resistance?

Back

They expel antibiotics from the bacterial cell, reducing drug concentration.

Front

What is the significance of the 50S ribosomal subunit in antibiotic action?

Back

It is a target for antibiotics that inhibit protein synthesis.