Acute Myeloid leukemia (AML)

Front

What is Acute Myeloid Leukemia (AML)?

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A type of cancer that affects the blood and bone marrow, characterized by the rapid growth of abnormal white blood cells.

Front

What is the blast percentage cut off for Acute Myeloid Leukemia (AML)?

Back

Depending on underlying genetic abnormalities percentage may vary.

Front

What factors define prognosis/risk stratification in patients with AML?

Back

Underlying mutational landscape and cytogenetic aberrations.

Front

What does Gemtuzumab target?

Back

Anti-CD33 antibody linked to cytotoxic agent.

Front

Name a targetable treatment used in acute myeloid leukemia.

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KMT2A-rearranged and NPM1 mutated - menin inhibitor Revumenib; FLT3 inhibitor - midostaurin; IDH1/2 inhibitors - Ivosidenib.

Front

What is the minimal mutational landscape necessary for efficient risk stratification using ELN guidelines?

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ELN guidelines require NPM1, FLT3, and CEBPA mutation status.

Front

What is the role of NPM1 mutations in AML?

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NPM1 mutations are associated with a favorable prognosis in AML.

Front

What is the significance of FLT3 mutations in AML?

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FLT3 mutations are linked to poor prognosis and are targetable with specific inhibitors.

Front

What is the function of the anti-CD33 antibody in AML treatment?

Back

It targets CD33 on the surface of leukemia cells, delivering cytotoxic agents to kill the cells.

Front

What are cytogenetic aberrations?

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Chromosomal abnormalities that can influence the prognosis and treatment of AML.