Analgesic Drugs and COX-1 Inhibitors

Front

What are drugs with strong analgesic effects that are effective COX-1 inhibitors?

Back

Ketorolac, ketoprofen, diclofenac sodium, naproxen.

Front

What are the common side effects of nonsteroidal anti-inflammatory drugs (NSAIDs)?

Back

Gastrointestinal issues, cardiovascular risks, kidney problems.

COX-1 inhibitors → more GI and bleeding side effects.

• COX-2 inhibitors → safer for stomach, but higher cardiovascular risk.

Front

Which COX enzyme is primarily responsible for the production of prostaglandins that mediate inflammation?

Back

COX-2.

Front

What is the mechanism of action of acetaminophen?

Back

It inhibits the synthesis of prostaglandins in the central nervous system.

Front

What is the primary use of ibuprofen?

Back

It is used to relieve pain, reduce inflammation, and lower fever.

Front

What is the difference between COX-1 and COX-2 enzymes?

Back

COX-1 is involved in the production of protective gastric mucosa, while COX-2 is primarily involved in inflammation.

COX-1 inhibitors → more GI and bleeding side effects.

• COX-2 inhibitors → safer for stomach, but higher cardiovascular risk.

Front

What are the potential risks associated with long-term use of NSAIDs?

Back

Increased risk of gastrointestinal bleeding, cardiovascular events, and renal impairment.

Front

What are the common contraindications for using NSAIDs?

Back

Peptic ulcer disease, severe renal impairment, and hypersensitivity to NSAIDs.

Front

How do NSAIDs affect platelet function?

Back

Aspirin has antithrombotic effect They can inhibit platelet aggregation that prevent stroke, and has adverse effect that increasing the risk of bleeding.

Front

• Why ibuprofen???
  

  ;)

Back

• Ibuprofen is considered one of the safest drugs in the NSAID group.

• Ibuprofen can be used during the 1st and 2nd trimesters of pregnancy.

• Ibuprofen is safe for use in children older than 6 months.

• Ibuprofen can be safely used by breastfeeding mothers.

• Ibuprofen in patients with a history of gastric problems and mild pain should be combined with a proton pump inhibitor (e.g., omeprazole, pantoprazole).

• Ibuprofen and naproxen are safer NSAID options in patients with heart problems.