FLASHCARD Huntington's disease treatment (24/09/25)

Front

How does the presenter characterize the news about Huntington’s disease treatment in the opening segment?

Back

As breaking news about a just-released trial

Front

Huntington’s disease is often described as a mixture of which three conditions, highlighting its combined cognitive and motor decline?

Back

Dementia, Parkinson’s, and motor neuron disease

Front

In the UK context given by the presenter, approximately how many people are affected by Huntington’s disease?

Back

Around 7,000 people

Front

What clarification does Fergus Walsh make about risk and certainty in inheritance?

Back

Children have a 50/50 chance to inherit the gene; if you inherit it, there’s a 100% chance you’ll develop the disease

Front

In terms of disease timeline, what typical life stage is mentioned for the onset of Huntington’s disease?

Back

Middle age

Front

What procedure was delivered to the participants according to Fergus?

Back

A one-off injection delivered into six parts deep in the brain

Front

What sample size does Fergus explicitly cite when summarizing the top-line three-year data from this study? Options: 92 patients, 29 patients, 49 patients, 19 patients

Back

29 patients

Front

The average slowing of Huntington’s disease progression reported over three years in this cohort was quantified how, based on the measured outcomes?

Back

75% average slowing

Front

Which outcome domains are named as being part of the measures used to assess the trial’s impact on participants’ daily functioning?

Back

Cognition, movement, and ability to lead an independent life

Front

How does Professor Edward Wild characterize the history of Huntington’s clinical trials before this result?

Back

Many trials with incremental progress but ultimately negative outcomes