1. DRUGS ACTING ON ENDOCRINE SYSTEM

Drugs ACTING ON ENDOCRINE GLAND

by TITIKSH

Multiple Choice

Steroids contains following numbers of rings

• 2

• 3

• 4

• 5

Multiple Choice

The basic skeleton of steroid is named as

• 1,3 cyclopentanophenanthrene

• 1,2 cyclopentanophenanthrene

• 1,2 cyclopentanoanthracene

• 1,3 cyclopentanoanthracene

Multiple Choice

In the nomenclature of steroids α (alpha) substituents are located on

• Above the plane

• Below the plane

• in Plane

• none of above

Multiple Choice

In the nomenclature of steroids BETA substituents are located on

• Above the plane

• Below the plane

• in Plane

• none of above

Multiple Choice

Following are basic skeletons of steroids except

• Gonane

• Estrane

• Androstane

• Nonane

Multiple Choice

Chiral centre in 5α cholestane are

• 6

• 5

• 4

• 3

Multiple Choice

Δ sign in name of steroid indicates

• Double bond

• Triple bond

• Single bond

• Both A and B

Multiple Choice

Nor in the name of steroid indicate

• Presence of Methyl group

• Absence of methyl group

• presence of double bond

• Absence of double bond

Multiple Choice

What is precursor for synthesis of sex hormone

• Lipids

• Cholesterol

• Amino acids

• Carbohydrates

Multiple Choice

find the odd from the options given below

• Diethylstibetrol

• ethynylestradiol

• Estrone

• Mestranol

Fill in the Blanks

The correct IUPAC name of estradiol is

Multiple Choice

prodrugs of estrogens can be made by making substitution at following positions

• 3,17

• 3,16

• 5,17

• 16,17

Fill in the Blanks

---- is reponcible for catalytic HYDROLYSIS of CGMP in smooth muscles of the artries of penis

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​t

​

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​These are contraindicated along with nitrates due to hypotension

Fill in the Blanks

PDE 5 inhibitors are generally contraindicated with ---------

Multiple Choice

one of following heterocyclic ring is not the part of structure of Tadalafil

• piperidine

• piprazine

• Indole

• imidazole

​

​

T3

​

​

​

T4

​3-methyl-1H-imidazole-2-thione

3-methyl-1H-imidazole-2-thione​

​6-propyl-2-sulfanylidene-1H-pyrimidin-4-one

Multiple Choice

The structure of methimazole has following heterocycle

• Imidazole

• Pyrazole

• PYRIDINE

• PYRIMIDINE

​Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

​3-methyl-1H-imidazole-2-thione​

​Propyl thiouracil

​6-propyl-2-sulfanylidene-1H-pyrimidin-4-one

​

​Propylthiouracil is a thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4).

Multiple Choice

Propylthiouracil has one of following heterocycle

• Urea

• Pyrimidine

• Purine

• THIAZOLE