DNA/RNA Mutations

DNA/RNA Mutations

We will understand mutations in DNA and RNA.

I will be able to identify and describe the effect of three types of mutations in DNA or RNA.

Drag and Drop

One basic unit of a Nucleic Acid is a​

Placeholder

Drag these tiles and drop them in the correct blank above

nucleotide

amino acid

fatty acid

monosaccharide

Drag and Drop

Three Nucleotides in a row of DNA or mRNA are called a...

Placeholder

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Codon

Sugar

Ribosome

acid

Protein

Open Ended

Given this DNA Sequence:

TAC TAG CCG AGT

What is the correct amino acid sequence?

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​Two Types of Mutations

Open Ended

What is the difference between

the effect of a point mutation and the effect of a frameshift mutation?

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​Substitution

​Mutation Type:
Point Mutation

When one nucleotide is changed out for another.

Affects: ONLY ONE Nucleotide

Poll

If one nucleotide is affected in a point mutation,

can this change the amino acid made?

• Yes, always

• No, never

• Sometimes

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Insertion

​​Mutation Type:
Frameshift Mutation

When one nucleotide is randomly added in

Affects: More than one Nucleotide
Shift Everything Right

Multiple Choice

If more than one nucleotide are affected in a frameshift mutation,

can this change an amino acid made? How many?

• Yes, but only one

• No, none

• Yes and possibly many or all

Deletion

​​​Mutation Type:
Frameshift Mutation

When one nucleotide is deleted from the code

Affects: More than one Nucleotide
Shift Everything Left

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Match

Match the following Mutations

• Deletion

• Insertion

• Substitution

• Point

• Frameshift

Entire sequence shifts to the left

Entire sequence shifts to the right

One Nucleotide is swapped for another

Only one nucleotide is affected

More than one nucleotide is affected and entire sequence shifts

• Entire sequence shifts to the left

• Entire sequence shifts to the right

• One Nucleotide is swapped for another

• Only one nucleotide is affected

• More than one nucleotide is affected and entire sequence shifts

Effects of DNA and RNA Mutations on
Amino Acids and Proteins

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​Causes one amino acid to CHANGE into a STOP codon

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​Causes amino acid sequence to CHANGE, making a DIFFERENT PROTEIN

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​Has NO EFFECT on amino acids or protein

Match

Match the following Mutations

• Missense

• Nonsense

• Silent

Causes chance in amino acid sequence ; results in different protein

Causes an amino acid to change into a "STOP" codon

Has no effect on amino acids or proteins

• Causes chance in amino acid sequence ; results in different protein

• Causes an amino acid to change into a "STOP" codon

• Has no effect on amino acids or proteins

Draw

Identify and Circle the Mutation

Fill in the Blank

What was the new amino acid made by this mutation?

Multiple Choice

What Type of mutation is this?

• Point

• Frameshift

Multiple Choice

What Sub-type of mutation is this?

• Substitution

• Deletion

• Insertion

Multiple Choice

What type of effect does this mutation have?

• Nonsense

• Missense

• Silent

Open Ended

What is a difference between

the effect of a point mutation and

the effect of a frameshift mutation?

We will understand mutations in DNA and RNA

I will be able to identify and describe the effect of three types of mutations in DNA or RNA.