7C Review

Mutations

​Gene Mutations

​Point Mutation:


1. Substitution: when 1 base is swapped with another, causing change in one amino acid.


2. Silent: when 1 base is swapped with another, having no effect on the amino acid.

​Frameshift Mutation:


1. Insertion: when a base is added to the sequence, causing a shift.


2. Deletion: when a base is deleted from the sequence, causing a shift.

​Substitution: The C (3rd codon) in the original strand was swapped for a T, which changed one amino acid.

​Silent: The letter A (5th codon) was swapped for the letter U, but the amino acid VAL did not change. Therefore, it had no effect.

​Insertion: The letter C was added into the sequence, which caused a shift in the sequence and will cause a change in multiple amino acids.

​Deletion: The letter T was removed from the sequence, which caused a shift in the sequence and will cause a change in multiple amino acids.

Multiple Choice

Which of the following type of mutation can be more harmful?

• Substitution

• Point

• Silent

• Frameshift

Multiple Choice

Which of the following type of mutation has no effect on the amino acid sequence?

• Substitution

• Silent

• Insertion

• Deletion

Drag and Drop

The two types of point mutations are​

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and ​

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.

The two types of frameshift mutations are ​

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and ​

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.

Drag these tiles and drop them in the correct blank above

substitution

silent

insertion

deletion

Hotspot

Which codon did the mutation occur?

Hotspot

Which codon did the mutation occur?

Hotspot

Which codon did the mutation occur?

Multiple Choice

What type of mutation is shown in the picture?

• Substitution

• Insertion

• Deletion

Multiple Choice

What type of mutation is shown in the picture?

• Substitution

• Insertion

• Deletion

Multiple Choice

What type of mutation is shown in the picture?

• Substitution

• Insertion

• Deletion

Match

Match the following mutation to its correct picture using the picture provided.

Substitution

Insertion

Deletion

• Substitution

• Insertion

• Deletion

Match

Match the following:

• 
  a change in the DNA sequence

• a type of mutation where one to few bases are substituted with different bases

• a type of mutation caused by adding or deleting bases, affecting all the codons after the change

• a type of mutation that doesn't result in a change in the amino acid sequence (same protein)

Mutation

Point Mutation

Frameshift Mutation

Silent Mutation

• Mutation

• Point Mutation

• Frameshift Mutation

• Silent Mutation

Match

Match the following

Insertion

Deletion

Substitution

• Insertion

• Deletion

• Substitution

Match

Match the following

• A nitrogen base is added

• A nitrogen base is removed

• One base is swapped for another

Insertion

Deletion

Substitution

• Insertion

• Deletion

• Substitution

Categorize

Options (7)

Substitution

Only one letter (base) is changed

Insertion

Deletion

Causes the entire DNA sequence to shift after the mutation

Would only impact 1 amino acid

Will change all amino acids after the mutation

Organize these options into the right categories

Point Mutation

Frameshift Mutation

Multiple Choice

Which of the following mutations will not change the amino acid

• Insertion

• Deletion

• Silent

Multiple Choice

Why are insertion and deletion (frameshift) mutations so harmful?

• They change all of the codons from the mutation on down the line, which changes the amino acid sequence

• They insert things that an organism doesn't need.

• They often delete things that organisms need.

• Insertion and deletions are not any more harmful than substitution mutations.

Multiple Choice

Which mutation will cause translation to stop?

• Mutations 1 and 3 only

• Mutation 1 only

• Mutation 2 only

• Muations 1, 2, 3

Multiple Choice

Which type of mutation is occurring in the picture?

• Insertion

• Deletion

• Substitution

Multiple Choice

This type of mutation will result in:

• all of the amino acids after the mutation will be different from the normal protein

• just one amino acid will be different from the normal protein

• all of the amino acids will be different both before and after the mutation

Multiple Choice

Which type of mutation is occurring in the picture?

• Insertion

• Deletion

• Substitution