Nucleic Acids

Dr. Ravi Prem Kalsait

M.Pharm.,Ph.D.,DBM.

Principal

Central India College of Pharmacy, Lonara, Nagpur ​

​

​Biosynthesis of Pyrimidine & Purine

​Nucleic Acid Metabolism & Genetic Information Transfer

• Nucleotides are the activated precursors of nucleic acids.

• An adenine/guanine nucleotide : ATP/GTP energy​ source for biological process

• Nucleotide derivatives e.g. UDP-glucose participate in Biosynthetic processes such as the formation of glycogen

• ​Nucleotides are essential components of signal-transduction pathways

• Cyclic nucleotides such as cyclic AMP and cyclic GMP are

  second messengers that transmit signals both within and between cells​

De Novo Method: Pyrimidine Ring Is Assembled from Bicarbonate, Aspartate, and Glutamine.​

​​Pyrimidine

​.....base is synthesized piece by piece directly onto a ribose-based structure

Purine...

...

​Purine or Pyrimidine (Bases)

​Addition of Ribose sugar

​Purine or Pyrimidine (Nucleosides)

​Purine or Pyrimidine (Nucleotides)

​Phosphorylation of base

​A

​G

T

​C

U

Poll

Adenine nucleotide ATP, is the universal currency of energy

• Yes

• No

• I dont Know

• r

Poll

An ample supply of Nucleotides is essential for many life processes

• Yes it is very Essential

• Yes but not that much essential

• Definitely without nucleotide there is no life and no human beign

• False

Multiple Choice

Cyclic AMP and Cyclic GMP

• Aliphatic Nucleotide

• Cyclic Nucleotide

• Alicyclic Nucleotide

• Bicyclic Nucleotide

Poll

Purine contains...

• Two Rings and Four Nitrogens

• Two Rings and Two Nitrogens

• One Ring and One Nitrogen

• Two Rings and One Nitrogen

Multiple Choice

Purine and Pyrimidines are

• Bases

• Acids

• Neutral Compounds

• Ions

Poll

Pyrimidine contains....

• Two Rings and Two Nitrogen

• One Ring and Two Nitrogen

• Two Ring and one Nitrogen

• Two Ring and four Nitrogen