Mitosis + checkpoints

Multiple Choice

During which phase of mitosis do microtubules begin attach to kinetochores?

• Prometaphase

• Metaphase

• Anaphase

• Telophase

Multiple Select

Which of the following events occur during metaphase?

• Chromosomes line up at the metaphase plate

• Centrosomes are at opposite poles

• Microtubules are attached to each kinetochore

• Nuclear envelope fragments

Multiple Choice

Which of the following accurately describes what happens during anaphase?

• Sister chromatids are separated and moved to opposite poles.
• Sister chromatids are duplicated and remain together.
• Sister chromatids align at the cell equator.
• Sister chromatids are randomly distributed in the cytoplasm.

Multiple Choice

Which of the follow is NOT a characteristics of telophase and cytokenesis?

• Alignment of chromosomes at the metaphase plate
• Chromosomes condense and become visible
• Nuclear envelope begins to reform
• One parent cell finishes separating into two daughter cells

Multiple Choice

Which of the following accurately lists the phases of mitosis in order?

• Anaphase, Prophase, Telophase,
  Cytokenesis

  Interphase

• Prophase,

  Prometaphase,

  Metaphase, Anaphase, Telophase,

  Cytokenesis

• Metaphase, Telophase, Prophase, Anaphase
• Prophase, Anaphase, Telophase,

  Interphase

  Cytokinesis

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Multiple Choice

What is the chromosome number in each daughter cell after mitosis if the parent cell is 2n=2?

• 2

• 4

• 1

• 8

Multiple Choice

Movement of the chromosomes during anaphase would be most affected by a drug that prevents:

• Nuclear envelope breakdown

• Cell wall formation

• elongation of microtubules

• Shortening of microtubules

• Formation of a cleavage furrow

Multiple Choice

Eukaryotic chromatin is composed of

• Condensed DNA only

• DNA and RNA

• DNA and Carbohydrates

• DNA and Protein

• DNA and Ribosomes

Multiple Choice

If a sperm cell contains 12 chromosomes, it comes from an animal that has ___ chromosomes

• 24
• 4

• 8

• 12

• 16

Open Ended

A cell has 50 chromosomes. After mitosis and cell division, you find that one daughter cell has 49 chromosomes and the other daughter cell has 51 chromosomes. Predict one way that this could have happened.

Multiple Choice

When in cell life does the G1 checkpoint occur?

• At the end of interphase

• During telophase

• During Anaphase

• At the end of the G1 phase of interphase.

Multiple Choice

Are cells in G0 dividing?

• No, cells in G0 are not dividing.
• G0 cells are in the process of division.
• Cells in G0 are preparing to divide soon.

Multiple Select

Which of the following are true about the G2 checkpoint?

• It checks for completion of DNA replication.

• It checks for DNA damage.

• It allows the cell to proceed to mitosis if conditions are met.

• It checks for microtubule attachment to chromosomes.

Multiple Choice

Which of the following statements about cyclins is correct?

• Cyclin concentration varies during the cell cycle.

• Cyclins are only synthesized during mitosis.

• Cyclins are never degraded.

• Cyclins are enzymes.

Multiple Choice

Which cyclin is most abundant during the G1 phase of the cell cycle?

• Cyclin D

• Cyclin E

• Cyclin A

• Cyclin B

​Growth Factor

​Anchorage dependence

Multiple Choice

Which of the following is NOT a characteristic of cancer cells compared to normal cells?

• They follow checkpoints

• They divide infinitely in culture

• They evade apoptosis

• They are considered 'immortal'

Open Ended

Explain the difference between benign and malignant tumors, and describe the process of metastasis.

Open Ended

Vinblastine is a chemotherapeutic drug often administered to patients suffering from Hodgkin’s lymphoma, lung cancer, and bladder cancer. Vinblastine works by entering cancer cells and binding to tubulin, which is a protein that forms microtubules. Once Vinblastine has bound to tubulin, it inhibits the assembly of microtubules and proper formation of the mitotic spindle. This causes the cell cycle to arrest. a) Identify and explain two phases of the cell cycle most affected by Vinblastine. b) Identify the checkpoint that is most likely responsible for arresting the cell cycle.