DNA Mutations

List the following in order from smallest to biggest:

Chromosome, DNA, Gene

• Chromosome --> DNA --> Gene

• Chromosome --> Gene --> DNA

• Gene --> DNA --> Chromosome

• DNA --> Gene --> Chromosome

Sickle cell disease is a genetic disorder that affects hemoglobin. In the gene that codes for hemoglobin, the normal codon sequence GAG becomes GUG. As a result, the amino acid glutamine is replaced with valine. What type of mutation causes sickle cell disease?

• Substitution

• Frameshift

• Deletion

• Inversion

Tags

NGSS.HS-LS3-2

A substitution mutation that occurs in a blood cell would most likely result in which of the following?

• Incorrect coding for a protein

• A very serious chromosomal mutation

• A recessive trait passed on to offspring

• A dominant trait passed on to offspring

Tags

NGSS.HS-LS3-2

NGSS.HS-LS1-1

Why is a frameshift mutation usually more serious than a substitution mutation?

• It can be passed on to offspring

• It changes EVERY codon after the mutation

• It always causes some form of cancer

• It causes duplication of genetic information

Tags

NGSS.HS-LS3-2

What type of mutation is shown in the diagram?

• Point mutation - missense

• Frameshift Mutation - deletion

• Frameshift Mutation - addition

• Point mutation - nonsense

Tags

NGSS.HS-LS3-2

NGSS.HS-LS1-1

A type of mutation that affect every codon beyond the point of mutation.

• Point Mutation

• Silent Mutation

• Nonsense Mutation

• Frameshift Mutation

A mutation is defined as:

• A change in the cell's structure

• Anything that changes in an embryo

• Any change in the physical features of a human

• A change in the DNA sequence

Tags

NGSS.HS-LS3-2

NGSS.HS-LS4-2

Where do mutations occur?

• DNA and RNA
• DNA 
• RNA
• mRNA and tRNA

Tags

NGSS.HS-LS3-2

NGSS.HS-LS4-2

ATTTGAGCC- Original

ATTGAGCC - Mutated

The example above is an example of a

• Insertion

• Point mutation

• Deletion

• Substitution

Tags

NGSS.HS-LS3-2

What mutation has occurred here? 
T-G-A-C-C-A
T-G-A-G-C-A

• Substitution
• Deletion
• Insertion
• Frameshift 

Tags

NGSS.HS-LS3-2