Quiz2A on Combinatorial Synthesis

Which of the following statement is false for Houghten's Tea bag Technology?

• It is a parallel synthesis

• Beads were contained in porous bags

• Porous bag with beads are dipped into reagent solutions.

• Identity of the peptide or peptides contained is not recorded on the attached label.

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Which of the following is false for Geysen's multi pin technology?

• It is the simplest and least ambiguous method

• It is a spatially separate

• Decoding sequence needs to be attached to the beads

• 96-well plate can be used

Boc-protected amino acid is bound to the resin as an ester by

• SN₁ reaction

• SN₂ reaction

• Addition reaction

• complexation reaction

Large number of -------- side chains on the bead meant that one bead acts as the solid support for the formation of a large number of peptide molecules of same type.

• Carboxylated

• Chlorinated

• Acylated

• Hydroxylated

Which terminal of first amino acid in peptide chain is attached to the bead in Marrifield Peptide synthesis?

• N- terminal

• C-terminal

Solid support of SPPS is

• copolymer of styrene

• copolymer of divinyl benzene

• Polystyrene cross-linked with divinyl benzene

The function of linkage agent is

• To link the protecting group with amino acid

• To link the amino acid with solid support

• To link the protecting group with solid support

Benzyloxy carbonyl group can be easily cleaved from the amino acid to produce free amino group by

• Hydrogenolysis

• Oxidation

• Hydrolysis

• Chlorination

Which of the following is a better leaving group?

• Methyl

• Ethyl

• Benzyl

• p-Nitrophenyl

The addition product of Z-protected amino acid to DCCI acts as

• Reducing agent

• Oxidising agent

• Acetylating agent

• Chlorinating agent