Topic 4: Solid Phase Peptide Synthesis

Topic 4: Solid Phase Peptide Synthesis

University

11 Qs

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Topic 4: Solid Phase Peptide Synthesis

Topic 4: Solid Phase Peptide Synthesis

Assessment

Quiz

Chemistry

University

Practice Problem

Medium

Created by

Alex B

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11 questions

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1.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the primary purpose of Merrifield solid phase synthesis in peptide chemistry?

To increase the solubility of peptides

To facilitate the sequential addition of amino acids

To ensure amino acids do not epimerize

To avoid the need for hazardous reagents

2.

MULTIPLE SELECT QUESTION

45 sec • 1 pt

Which reagent(s) is(are) commonly used for the activation of carboxylic acids in peptide synthesis?

Uronium compounds (HBTU)

Carbodiimide (DIC)

Thionyl chloride

ATP

3.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the role of uronium reagents in peptide synthesis?

To protect amino acid side chains

To deprotect the Fmoc group

To activate carboxylic acids

To neutralise acids

4.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following is a common method for Fmoc deprotection in peptide synthesis?

Treatment with trifluoroacetic acid

Treatment with piperidine

Treatment with hydrochloric acid

Treatment with sodium hydroxide

5.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the main advantage of using protecting groups for amino acid side chains in peptide synthesis?

To increase the molecular weight of peptides

To prevent unwanted side reactions

To increase their solubility in organic solvents

To decrease the solubility of peptides

6.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following is a commonly used protecting group for the amino group in peptide synthesis?

Boc (tert-butyloxycarbonyl)

Acetyl

Benzyl

Methyl

7.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

In Merrifield solid phase synthesis, what is the solid support typically made of?

Glass beads

Polystyrene resin

Silica gel

Cellulose

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