Bilirubin and jaundice

On an average, how much bilirubin is formed in a day

• 25 - 35 mg

• 250 - 350 mg

• 2500 - 3500 mg

A patient with high bilirubin levels takes aspirin (acetyl salicylate) and experiences neurologic problems. This is most probably because which of the following?

• Displacement of bilirubin from albumin

• Decreased hepatic uptake of bilirubin

• Decreased conjugation of bilirubin

• Decreased secretion of bilirubin conjugates in bile

Which of the following are released in the reaction catalyzed by heme oxygenase? (Check all that apply)

• CO

• Iron

• NADP

• Biliverdin

• Oxygen

Unconjugated bilirubin enters the hepatocytes mainly through which of the following mechanisms?

• Simple diffusion

• Active transport

• Facilitated diffusion

Glucuronic acid required for conjugation of bilirubin is derived from which of the following?

• Albumin

• Glucose

• Cholesterol

• Fatty acids

In comparison to unconjugated bilirubin, conjugated bilirubin (Check all that apply)

• Is more soluble

• Is less toxic

• Can be excreted in urine

Which of the following is the rate-limiting step in bilirubin metabolism?

• Hepatic uptake

• Hepatic conjugation

• Secretion into bile

• Conversion to urobilinogen

A patient has yellowish discoloration of skin and sclera but his urine does not show deep yellow color. He most probably has

• Prehepatic jaundice

• Hepatic jaundice

• Posthepatic jaundice

G6PD deficiency is characterized by (check all that apply)

• Increased unconjugated bilirubin in blood

• Increased urobilin in urine

• Decreased stercobilin in feces

• Presence of bilirubin in urine

A patient has yellowish discoloration of skin & sclera, passes pale stools and his urine has a deep yellow color. He most likely has which of the following types of jaundice?

• Hemolytic

• Hepatic

• Obstructive