Thalassemia

Which type of hemoglobin does B-thalassemia affect?

• Hemoglobin F (HbF)

• Hemoglobin A (HbA)

• Hemoglobin A2 (HbA2)

• Hemoglobin B (HbB)

Which of the following is NOT a symptom of B-thalassemia?

• Chipmunk face

• Hair-on-End Skull Xray

• Hepatosplenomegaly

• Moon face

what was the allocation ratio in the RCT (Luspatercept Vs Placebo) ?

• 1:1

• 2:1

• 3:1

• 2:3

the most common SE of grade 3 or higher in the luspatercept are:

• Anemia\ Increased Iron liver concentration\ Hyperuricemia

• Bone pain\ arthralgia\ vomiting

• dizziness\ anemia\ hypertension

• Back pain\ bone pain\ dizziness

Luspatercept mechanism of action (class):

• Erythroid maturation agent: restores RBC production

• Epoetin alfa analogue

• Multivitamin with iron

• Heavy metal antagonists: Iron-binding agent

List a limitation to the study: