Medical Interventions 2.2.1

The alteration of the genes of a person afflicted with a genetic disease is known as _____________.

• a point mutation

• a vector

• gene therapy

• Biotechnology

Tags

NGSS.HS-LS3-2

What is the best definition of a vector?

• a quantity that has magnitude and direction. It is represented by an arrow.

• an organism/virus that transmits a pathogen or nucleic acid from itself to another.

• a person's name

• a DNA particle that is transferred from one organism to the next.

There are three general strategies to gene therapy. Select the ones below that are NOT a strategy.

• Insert a functional gene into a patient

• Remove an extra chromosome or add a missing chromosome into a patients' cells.

• Fix a cell in vivo by using exocytosis to insert a cell part.

• Disable a gene so that the impact of the protein is eliminated

• Repair a dysfunctional gene so it produces a functional protein.

Tags

NGSS.HS-LS1-1

Of the 7 vectors studied in Act. 2.2.1, which is one you have worked with already in MI this year?

• Liposome

• Adeno-associated Virus

• Retrovirus

• Plasmid

Of the vectors studied in Act. 2.2.1, which of the vector choices below would trigger an immune response from it's host?

• Plasmid

• Liposome

• Herpes Virus

• Adeno-associated virus

• Adenovirus

Why would a liposome be the best choice as a vector to deliver gene therapy to a defective cell?

• It can handle any sized nucleic acid

• It has a low efficiency of getting the gene to it's target cell.

• It can only handle genes that are less than 5000 bp in length.

• It delivers genes to hepatic tissues primarily.

Tags

NGSS.HS-ETS1-3

____________ therapy is beneficial because there is a low likelihood of immune response. It ensures the vector goes to the correct cell. However, patients do have to wait longer to receive the benefits of this particular gene therapy.

A mutation in this gene is responsible for the genetic disorder Cystic Fibrosis.

• FVII

• aneuploidy at chromosome 21

• CFTR

• TAS2R38

Tags

NGSS.HS-LS3-2

Which of the following is false of Cystic Fibrosis?

• The faulty gene makes a bad transmembrane conductance regulator protein

• Lung and pancreatic tissues are greatly affected.

• chloride ions aren't shuttled out of the cells. Sodium builds up in the cells dehydrating the mucus making it thick.

• Chronic respiratory infections are a problem, but not pancreatitis.

Tags

NGSS.HS-LS3-1

NGSS.HS-LS3-2

Which vector of the choices below would be the best candidate to use for gene therapy in individuals with Cystic Fibrosis?

• Plasmid

• Adeno-associated virus

• Herpes Virus

• Retrovirus