B cell activation,generation and proliferation

During the B cell maturation,which of the following stage expresses surrogate light chain complexed with the heavy chain?

• Pro-B cell

• Pre-B cell

• Immature B cell

• Mature B cell

The lymphoid stem cells commit for B cell lineage and differentiate into pro-B cells in bone marrow.Which of the cell surface marker is expressed in pro-B cells?

• CD25

• CD25R

• CD45

• CD45R

Which of the following cell surface marker is not expressed throughout the B cell maturation process from pro B cell to Mature B cell

• CD19

• Ig $\alpha$ /Ig $\beta$

• CD24

• IgD/IgM

Which of the following cell surface marker constitutively expressed on B cell activations?

• CD22

• CD40

• Ig $\alpha$

• Ig $\beta$

Which of the following is not true regarding thymus-dependent antigens?

• Induce isotype switching

• Induce affinity maturation

• Possess immunological memory

• Always induce polyclonal activation of B cells

Omen syndrome is characterized by the presence of pruritic skin,fever,lymphadenopathy,anemia and eosiophilia.Which of the following condition may present as Omen syndrome?

• RAG gene deficiency

• X-linked CD40 ligand deficiency

• CD40 deficiency

• None of the above

A patient present with a history of recurrent respiratory tract infection and exhibited reduced concentration of all classed of immunoglobulins.The genetic testing shows a mutation of RAG1 and RAG2 genes.What are the function of RAG1 and RAG2 protiens?

• Signal B cell activation

• Rearrange heavy chains of immunoglobulins

• Inducing Affinity maturation

• Induce Isotype switching

The B cell receptors interact with the B cell co-receptors for effective signaling.What is the component of the B cell co-receptor complex?

• CD19,CD21(CR2),CD81

• CD19,CD45,CTLA-4

• CD10,CD22,CD81

• None of the above

Thymus-independent antigens activate B cells without the help of T-helper cells.These molecules include

• Lipids

• Lipopolysaccharide

• Polysaccharide

• Protiens

B1B cells are self-renewing B cell subset.Which of the following is true regarding B1B cells?

• B1B cells compose of 95% of the total B cell population

• B1B cells express numerous IgD molecule in their cell surface

• CD5 is an indispensable component of the B1 lineage

• B1 population responds poorly to carbohydrate antigens