Up until cotranslational translocation

The movement of proteins across the nuclear membrane through nuclear pores, occurs due to?

• ATP / ADP concentration gradient

• GTP / GDP concentration gradient

• Ran-GAP / Ran-GEF concentration gradient

• Ran-GTP / Ran-GDP concentration gradient

Ribosomes in the cytosol and in the ER are different in...

• Their function

• Their structure

• Their function and structure

• They are not different

This protein interacts with both the nuclear inner membrane and chromatin

• Kinase

• Telomerase

• Lamins

• Histones

Proteins produced by the secretory pathway are targeted to: (more than one answer might be correct)

• Lysosome

• Golgi

• Secretory vesicles

• Plasma membrane

What indicates that a protein must go through the secretory pathway?

The ERSS is located at the:

• Ribosome

• Endoplasmic reticulum

• The C terminus of a protein

• The N terminus of a protein

What drives the transfer of a protein through the translocon into the ER?

• ATP hydrolysis

• GTP hydrolysis

• Transcription

• Translation

Transmembrane sequences are:

• Hydrophilic

• Hydrophobic

• Amphiphilic

Multi-transmembrane proteins have...

• Stop transfer sequence

• Start transfer sequence

• Signal recognition particle

• Alternating stop and start transfer sequences

What is the positive inside rule?

• The N side will always be in the cytosolic domain since it is the most positive

• The C side will always be in the cytosolic domain since it is the most positive

• The N or C with the most positive charge will be on the cytosolic domain

• The N or C with the least positive charge will be on the cytosolic domain