Clin Lab Exam III - GI labs

LFTs include which of the following?

• Transaminases (ALT, AST)

• Alkaline phosphatase

• Total bilirubin

• Albumin

• Protein

Which of the following not a function of the liver?

• Makes bile and recycles old RBCs

• Metabolizes drugs and filters the blood

• Aids in digestion and performs gluconeogenesis

• Makes clotting factors and platelets

• Stores bile between meals and synthesizes RBCs

This enzyme found only in liver tissue and when elevated is suggestive of hepatocellular injury.

• Aspartate aminotransferase (AST)

• Alanine aminotransferase (ALT)

• Erythropoietin (EP)

• Alkaline phosphatase (ALP)

Common causes which may result in ALT and AST that are elevated <5 times the UNL (AST: 10-40 u/L, ALT: 7-56 u/L) includes which of the following?

• Alcohol abuse

• Cirrhosis

• Chronic hepatitis B or C

• Steatosis or steatohepatitis

• Medications and toxins

Evaluation of liver chemistries include all of the following except

• PTT and CBC with PLTs

• Hepatitis A,B,C serotypes

• serum iron, TIBC, ferritin

• Lipase and amylase

A patient presents to the ED for abdominal pain. LFTs show transaminitis with ALT of 75 (10-40 u/L) and AST of 187 (7-56 u/L). This ALT:AST ratio is indicative of which of the following?

• Acute hepatic injury

• EtOH injury

• Acute viral hepatitis

• Drug/toxin induced hepatitis

Medications classes that can cause LFT elevations include which of the following?

• NSAIDs

• β-blockers and CCBs

• PPIs

• Antibiotics & antifungals

• TCAs and anticonvulsants

The most common cause of acute liver failure in the US is?

• Acetaminophen

• Hepatitis infection

• Pregnancy

• Wilson's Disease

A patient with a hx of IVDA is admitted to the ICU after being found to have acute liver failure. 2 weeks later his ALT and AST have returned to WNL, but he has hypoalbuminemia, an increased PTT, and thrombocytopenia. Which of the following would be you be most concerned about in this patient?

• Acute Hepatitis

• Chronic Hepatitis

• Cirrhosis

• Fulminant liver failure

Markedly high transaminitis with ALT:AST >5x UNL (AST 10-40 u/L, ALT 7-56 u/L) raises concern for which of the following?

• Cirrhosis

• Acute viral hepatitis

• Toxin/drug induced hepatitis

• Ischemia/Infarction

• NAFLD