Resp - Exam 2 - Biologics Keshvara

"mab" means

• humanized

• monoclonal antibodies

• antibodies

• animalized

"zu" means

• humanized

• monoclonal antibodies

• antibodies

• animalized

What reactions can occur when taking a biologic drug

• potentially trigger injection site reactions

• potentially have systemic allergy symptoms

• can cause tiredness on day of injection

• can cause fatigue on day of injection

• can cause headache on day of injection

What interleukin(s) play a role asthma inflammation

• IL-4

• IL-5

• IL-9

• IL-13

What mediators are targeted by biologics for asthma

• IL-4

• IL-5

• IL-9

• IL-13

• IgE

What are some characteristics of Omalizumab (Xolair)

• humanized monoclonal antibody against IgE

• prevents binding of IgE to mast cells, prevents hypersensitivity driven by IgE

• injection 150-375 mg sc Q2-4 wks

• prevents binding of IL-13 to mast cells, prevents hypersensitivity driven by IL-13

• humanized monoclonal antibody against IL-13

What are some adverse effects of Omalizumab (Xolair)

• aches, pains

• anaphylaxis (BBW); can happen within 24 hr of any dose

• oropharyngeal pain

• cough

• headache

Omalizumab (Xolair) is dangerous because you can have anaphylaxis after ANY dose

• true

• false

What are some characteristics of Mepolizumab (Nucala)

• humanized monoclonal antibody against IL-5

• binds to IL-5, prevents recruitment of eosinophils

• injection 100 mg sc Q4 weeks

• binds to IL-13, prevents recruitment of eosinophils

• humanized monoclonal antibody against IL-13

Answer explanation

Tx for Eosinophilic asthma

What are some adverse effects of Mepolizumab (Nucala)

• aches, pains

• anaphylaxis (BBW); can happen within 24 hr of any dose

• oropharyngeal pain

• cough

• headache