Pharmaceutical Organic chemistry-II

Identify most deactivating meta directing group

• Amine

• Phenyl

• Alkoxy

• Nitro

Electrophile in Friedel Craft’s Acylation is

• RCO+

• RCO-

• R+

• R-

Identify the regent to convert amines into amides

• RX

• Acetic acid

• Sulphonyl chloride

• Benzoyl chloride

Benzoic acid can be converted to m-nitrobenzoic acid by

• Nitrous acid

• Sulphuric acid

• Nitric acid

• Nitric acid +Sulphuric acid

Iodination of fatty acids can be done by

• Potassium hydroxide

• Potassium permaganate

• Iodine

• IBr

Friedel crafts alkylation in naphthalene takes place at C-2 position due to

• Formation of stable resonating structure

• Stable hybrid structure

• Less kinetic energy

• No hindrance effects

Naphthalene on nitration results in to

• 2- Nitro naphthalene

• 1- Nitro naphthalene

• 4- Nitro naphthalene

• 3- Nitro naphthalene

Starting material for synthesis of naphthalene by Howarth method’s is

• Benzene

• Toluene

• Aniline

• Nitrobenzene

The cyclopropane is basically

• Planar in nature

• Non planar in nature

• Axial in plane

• Perpendicular to plane

Addition of HBr to 1,1-dimethylcyclopropane gives

• 2-Bromo butane

• 2-Bromo-2-methyl butane

• 3-Bromo butane

• 4-Bromobutane