Respiratory Pharmacology 1

Which desensitization mechanism is not reversible?

• short-term desensitization

• long-term desensitization

• chronic desensitization

• Hmmm.....

PDE inhibitor increase the level of cAMP/cGMP by preventing the degradation of cAMP/cGMP.

• True

• False

• Hmmm.....good question

Which ONE of the following statements about bronchodilator is correct?

• Short-acting bronchodilator is used as a preventer medicine in asthmatic patients

• b2-adrenoceptor agonist prevents late phase in asthma caused by release of cytokine

• b2-adrenoceptor agonist increases cAMP level, leading to airway relaxation

• Decrease in cAMP prevents mast cell degranulation

Desensitization of B2-adrenoceptor agonist can be prevented by _____?

• nifedipine

• beclometasone

• roflumilast

• ipratropium

How does steroid prevent desensitization of b2-adrenoceptors?

• Steroid transports the internalized b2-adrenoceptors back to plasma membrane

• Steroid increases the gene transcription of b2-adrenoceptors

• Steroid binds to b2-adrenoceptors, inhibiting the internalization of the receptors

• I don't like chocolate...