Session 1: Signaling across Membranes

Session 1: Signaling across Membranes

University

9 Qs

quiz-placeholder

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Session 1: Signaling across Membranes

Session 1: Signaling across Membranes

Assessment

Quiz

Biology

University

Hard

Created by

Helen May-Simera

Used 6+ times

FREE Resource

9 questions

Show all answers

1.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

The apoptosis intrinsic pathway occurs because:

caspases are released from the mitochondria

a death ligand binds to a death receptor

execution signals (cyt-c,…) are released from the mitochondria

Bcl2 family proteins degrades cellular proteins

2.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

The Bcl2 family proteins:

interact exclusively through their soluble domains to control apoptosis

antiapoptotic members (Bcl-xL, Bcl-2,…) interact with caspases to prevent cell death

proapoptotic members (Bax, Bak,…) form heteromeric pores at the mitochondrial outer membrane to release large execution signals (cyt-c, SMAC,…)

heteromeric interactions among the transmembrane domains of pro- and antiapoptotic members modulate apoptosis

3.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

To design an efficient Bcl-xL inhibitor:

it is mandatory to have the structure of the transmembrane interactions as a starting point

it is possible to computationally design inhibitors based only on the sequence of the C-terminal transmembrane domain

only soluble regions are good targets for inhibitor design

the designed sequences always work as predicted by the models

4.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following information is incorrect?

Internal membranes are exclusively found in eukaryotic cells

Membranes are dynamic structures.

Protein adhesion to membrane surfaces can result in membrane protection.

Membrane repair can involve vesicle formation.

5.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Mark the correct answer:

Bacterial members of the ESCRT-III superfamily ….

remain monomeric in solution.

form large β-barrel structures in solution.

form large helical assemblies in solution.

are always membrane-attached.

6.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the main function of proteins belonging to the Dynamin superfamily?

Binding to DNA in the nucleus

Remodeling membranes

Generating a transmembrane proton gradient in the respiratory chain

Inactivation of reactive oxygen species (ROS)

7.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

How is low pH affecting enterovirus infection?

lowering entry and therefore lowering infectivity

allowing entry but blocking viruses in early endosomes 

no effect on infectivity

increasing infectivity

8.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What methods would not be used to quantify virus proliferation in cells:

qPCR of the viral RNA

cytopathic effect evaluation by microscopy

sucrose gradient sedimentation of viruses

confocal microscopy to evaluate the amount of capsid proteins

9.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What does virus uncoating mean?

virus proliferation

sorting capsid proteins for capsid assembly

process where genome is released from the capsid

virus binding on cell surface receptors