The apoptosis intrinsic pathway occurs because:

Session 1: Signaling across Membranes

Quiz
•
Biology
•
University
•
Hard

Helen May-Simera
Used 6+ times
FREE Resource
9 questions
Show all answers
1.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
caspases are released from the mitochondria
a death ligand binds to a death receptor
execution signals (cyt-c,…) are released from the mitochondria
Bcl2 family proteins degrades cellular proteins
2.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
The Bcl2 family proteins:
interact exclusively through their soluble domains to control apoptosis
antiapoptotic members (Bcl-xL, Bcl-2,…) interact with caspases to prevent cell death
proapoptotic members (Bax, Bak,…) form heteromeric pores at the mitochondrial outer membrane to release large execution signals (cyt-c, SMAC,…)
heteromeric interactions among the transmembrane domains of pro- and antiapoptotic members modulate apoptosis
3.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
To design an efficient Bcl-xL inhibitor:
it is mandatory to have the structure of the transmembrane interactions as a starting point
it is possible to computationally design inhibitors based only on the sequence of the C-terminal transmembrane domain
only soluble regions are good targets for inhibitor design
the designed sequences always work as predicted by the models
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following information is incorrect?
Internal membranes are exclusively found in eukaryotic cells
Membranes are dynamic structures.
Protein adhesion to membrane surfaces can result in membrane protection.
Membrane repair can involve vesicle formation.
5.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Mark the correct answer:
Bacterial members of the ESCRT-III superfamily ….
remain monomeric in solution.
form large β-barrel structures in solution.
form large helical assemblies in solution.
are always membrane-attached.
6.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is the main function of proteins belonging to the Dynamin superfamily?
Binding to DNA in the nucleus
Remodeling membranes
Generating a transmembrane proton gradient in the respiratory chain
Inactivation of reactive oxygen species (ROS)
7.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
How is low pH affecting enterovirus infection?
lowering entry and therefore lowering infectivity
allowing entry but blocking viruses in early endosomes
no effect on infectivity
increasing infectivity
8.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What methods would not be used to quantify virus proliferation in cells:
qPCR of the viral RNA
cytopathic effect evaluation by microscopy
sucrose gradient sedimentation of viruses
confocal microscopy to evaluate the amount of capsid proteins
9.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What does virus uncoating mean?
virus proliferation
sorting capsid proteins for capsid assembly
process where genome is released from the capsid
virus binding on cell surface receptors
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