Journal Club

Kabuki syndrome is caused by a mutation in which genes?

• KMT2D or KDM6A gene

• KMT2D or HCAC gene

• FML69 or H3EK gene

• GLPR1 or EGFR gene

What do HDAC inhibitors do?

• They inhibit histone deacetylases and promote open chromatin states

• They inhibit histone acetyltransferases and promote closed chromatin states

What does the Morris Water Maze (MWM) evaluate?

• Gene expression

• Chronic stress-related anhedonia

• Hippocampal-dependent memory and learning

• Anxiety-like behavior

Why is the 50th intron chosen for the insertion of the cassette in the knock out KMT2D mice?

• Because the SET domain is upstream that intron

• Because the SET domain is downstream that intron

• The insertion is not in intron 50

• It is a random choice

Which one is not part of the indicators used for allele reporter assay?

• Histone core

• GFP

• Reader

All of these genes increased in transcript expression in response to ketogenic diet except:

• Glp1r

• Kmt2d

• Zic5

• Pld5