Haematological Functions of the Spleen

The spleen is located in the

• right iliac fossa..

• right lower quadrant.

• left coastal margin.

• left lower quadrant

The following statements are TRUE regarding spleen, EXCEPT

• The red pulp of the spleen is highly vascular.

• White pulp of the spleen is composed of lymphoid aggregates.

• lymphoid nodules in the white pulp is composed mainly of B-lymphocytes

• periarteriolar lymphoid sheath is composed mainly of B-lymphocytes

Which of the following BEST explains the cause of splenomegaly in chronic myeloid leukaemia.

• production of antibody

• control of red cell integrity

• extramedullary haematopoiesis

• sequestration of formed elements

Which of the following BEST explains the splenomegaly seen in hereditary spherocytosis

• phagocytosis of red blood cells by the splenic macrophages

• pooling of red blood cells in

• extramedullary haematopoiesis

Splenectomy results in the following changes in the full blood count EXCEPT

• further reduction in the Hb level

• neutrophilic leucocytosis

• lymphocytosis

• thrombocytosis

Splenectomy results in the following changes in the peripheral blood film EXCEPT

• target cells

• Howell jolly bodies

• reticulocytosis

• Basophilic stippling

Which of the following conditions can result in functional hyposplenism?

• chronic myeloid leukaemia

• sickle cell anaemia

• hairy cell leukaemia

• Gaucher's disease

Which of the following is the MOST feared complication post splenectomy?

• anaemia

• lymphocytosis

• thrombosis

• sepsis