KICK OFF QUIZ AND QUIZ 1 PK

Which of the following is TRUE when you administered the drug by intravascular route?

• No absorption phase

• Absorption phase

Which of the following it is used to assess kidney function and adjust dose of a drug?

• Systemic Clearance

• Creatinine clearance

• AUC

• Absorption

• Excretion

Which of the following apply to the rate of absorption when a drug is administered extravascular and follows the first order process (Select all that apply)

• A- It is directly proportional to the administered dose

• B- It is independent of the route of administration

• C- It is independent of the chosen dosage form

• D- It must decline with time

• E- It is independent of dose administered

Which of the following is true when an orally administered drug exhibits the

characteristics of a one compartment model?

• A- Absence of distribution phase

• B- There are two phases to the plasma concentration versus time graph

• C- A mono exponential equation can describe the data accurately

• D- Absence of an absorption phase

• E- The distribution equilibrium is attained at a finite time

Which of the following apply if the administered drug exhibits the characteristics of a first order process?

• A- Active transport

• B- Linear pharmacokinetics

• C- Unit for the rate is always reciprocal of time

• D- R. L. Plot of rate against time will yield a straight line with a negative slope

• E- Rate remains unchanged with time

Which of the following drug property plays a deciding role in choosing an appropriate compartment model, following the administration of a drug?

• A- Absorption

• B- Distribution

• C- Dissolution

• D- Elimination

• E- Metabolism

Which of the following permits the characterization of ADME processes following the administration of a drug?

• A- Bioavailability

• B- Diffusion & dissolution

• C-Biopharmaceutics

• D- Compartment modeling

• E- Pharmacokinetics

Onset of action, time of occurrence of highest plasma concentration, and the

absorption phase are three striking differences between intravascular and extravascular routes of drug administration.

• True

• False

Which of the following is true when compartmental concept is applied to describe the kinetics of drugs accurately?

• A- Administered drug follows the first order process

• B- Administered drug follows a zero-order process

• C-The concept is applicable for urinary as well as plasma concentration data

• D- The concept is applicable only when a drug is administered intravenously

• E- Distribution equilibrium will always be attained instantaneously

Which of the following best describes the term distribution?

• A- It is the reversible transfer of a drug from the Gl tract to the blood

• B- It is the irreversible transfer of drug from blood to urine

• C- It is the reversible transfer of drug from blood to urine

• D- It is the irreversible transfer of a drug from blood to various tissues and organs

• E- It is the reversible transfer of a drug to and from blood to various tissues and organs