HEMA 1 & 2

1. The clinical presentation of platelet-related bleeding may include all of the following except:

• Bruising

• Nosebleeds

• Gastrointestinal bleeing

• Bleeding into the joints (hemarthroses)

A defect in GP IIb/IIIa causes:

• Bernard-Soulier syndrome

• Glanzmann thrombasthenia

• Storage pool disease

• Gray platelet syndrome

Aspirin ingestion blocks the synthesis of:

• Ionized calcium

• Thromboxane A2

• ADP

• c. Collagen

Patients with Bernard-Soulier syndrome have which of the following laboratory test findings?

• Abnormal platelet response to arachidonic acid

• Abnormal platelet response to ristocetin

• Abnormal platelet response to collagen

• Thrombocytosis

The impaired platelet function in myeloproliferative neoplasms results from:

• Decreased numbers of a- and dense granules

• Abnormally shaped platelets

• Extended platelet life span

• Increased procoagulant activity

Which of the following is the most common of the hereditary platelet function defects?

• Glanzmann thrombasthenia

• Bernard-Soulier syndrome

• Storage pool defects

• Multiple myeloma

A mechanism of antiplatelet drugs targeting GP IIb/IIIa function is:

• Direct binding to GP IIb/IIIa

• Inhibition of transcription of the GP IIb/IIIa gene

• Interference with platelet adhesion to the subendothelium by blocking of the collagen binding site

• Interference with platelet secretion

Which is a congenital qualitative platelet disorder?

• Henoch-Schönlein purpura

• Senile purpura

• Waldenström macroglobulinemia

• Ehlers-Danlos syndrome

In uremia, platelet function is impaired by higher than normal levels of:

• Uric acid

• Urea

• NO

• Creatinine

The platelet defect associated with increased paraproteins is:

• Impaired aggregation because the hyperviscous plasma prevents platelet-endothelium interaction

• Hypercoagulability because the increased proteins bring platelets closer together, which leads to inappropriate aggregation

• Hypercoagulability owing to antibody binding and membrane activation

• Impaired membrane activation owing to protein coating