Pre-Resource Quiz

What is the definition of leukaemia?

• The uncontrolled proliferation of lymphoid progenitor cells; replacing normal haematopoietic cells of bone marrow and infiltrating other organs

• Cancer of the bone marrow which results in the proliferation of abnormal or immature (blast) cells

• Cancer of the lymphatic system

• Cancer of the bone marrow which produces abnormal plasma cells

ALL most commonly effects which age group?

• Children under 5

• Children over 5

• People under 45

• People over 45

A mother is being counselled on the best therapy option for her 10 year old daughter with ALL. What is the most likely way that this condition will be managed?

• Multi-agent Dose intense chemotherapy

• Immunotherapy

• Radiotherapy

• Targeted therapy

A 70 year old patient presents with symptoms of fatigue and gingivitis. FBC shows low haemoglobin, platelets and neutrophils. A peripheral blood smear shows >20% myeloblasts, some of which contain auer rods.

 

What is the most likely diagnosis?

• AML

• ALL

• CLL

• CML

Auer rods are seen on a peripheral blood smear.

Which leukaemia subtype are auer rods associated with?

• ALL

• AML

• CLL

• CML

You are a diligent student. You sit at home and reflect on a patient with leukaemia that you saw on the haematology ward. You can't remember which leukaemia it was but you remember the consultant saying it was the most common leukaemia in adults.

 

Which subtype did the patient have?

• ALL

• AML

• CLL

• CML

Which of the following are associated with CLL?

• Auer rods

• Philadelphia chromosome

• Smudge cells

• Down’s syndrome

Richter’s transformation occurs in 3-7% of CLL patients. 

 

What disease can CLL transform into?

• ALL

• Myeloproliferative disorder

• Diffuse large B cell lymphoma

• AML

Presence of which of the following would make a diagnosis of CML more likely? 

• Philadelphia chromosome

• Smudge cells

• Bone pain

• Lymphocytosis

A female patient is 66 and asymptomatic. She is discussing treatment options for CML with her doctor. 

 

What is the recommended management for this patient?

• Conservative management and monitoring

• Multi-agent dose intense chemotherapy

• Rituximab

• Ibrutinib (targeted therapy