Tut 2

Which of the following best describes drugs that undergo one-compartment elimination kinetics when a single dose is administered intravenously?

• Plasma concentrations fall exponentially over time

• Plasma concentrations decline rapidly initially followed by a relatively slower rate of decline over time

• Plasma concentrations fall at a constant rate over time

• Plasma concentrations fluctuate over time

Which of the following best describes a drug which is eliminated by first-order kinetics?

• A constant amount of the drug will be eliminated per unit time

• Its clearance value will remain constant

• Its elimination half-life will increase with dose

• It will be completely eliminated from the body in 2 times half-life period

Through which of the following route of administration is the bioavailability of a drug equals to 1?

• Intravenous

• Oral

• Sublingual

• Subcutaneous

Clearance is a reliable index of an individual's capacity to eliminate a drug. It is used to determine the

• half-life

• loading dose

• maintenance dose rate

• volume of distribution

For a drug with a half-life of 2.5 hours, steady-state is achieved after how many hours of administration in repeated dosages?

• 6.5h

• 9.0h

• 12.5h

• 15.0h

Which of the following determines the dosing interval of a drug during multiple dosing?

• Volume of distribution

• Elimination half-life

• Steady-state plasma concentration

• Oral bioavailability

The steady state plasma concentration of a drug administered by intravenous infusion is achieved in

• five half-lives

• one half life

• ten half-lives

• two half-lives

Which of the following refers to 'mutagenicity' of a drug?

• Causing physical dependence

• Cause genetic defects

• Cuse iatrogenic diseases

• Cause foetal abnormalities

Which of the following is the characteristic of Type A adverse drug reaction?

• Allergic

• Idiosyncratic

• Dose dependent

• Teratogenic

A patient is diagnosed with tuberculosis and treated with isoniazid. He later develops hepatoxicity and was found to be a fast acetylator. One of the following is the reason for the patient developing hepatoxicity:

• Side effect

• Toxic effect

• Secondary effect

• Idiosyncrasy