Narcotic Analgesics + NSAIDs

Identify the drug given below

• Ibuprofen

• Indomethacin

• Naproxen

• Sulindac

Mefenamic acid belongs to which chemical class of anti-inflammatory agents?

• Heteroaryl acetic acid derivatves

• Heteroaryl propionic acid derivatves

• Enolic acid derivative

• Anthranilic acid derivative

Incorporating a cyclopropylmethyl substitution at the 17th position of the multicyclic opioid ring leads to ______

• Agonistic activity predominates

• Reduced affinity to receptor

• Antagonistic activity predominates

• Mixed acting action

Which of the isomer of Sulindac is more active?

• R isomer

• S isomer

• E isomer

• Z isomer

Which of the following is a narcotic antagonist?

• Levorphanol

• Meperidine

• Naloxone

• Fentanyl

Biologic activity of Ibuprofen resides almost exclusively in the ______ isomer

• S-(-)

• S-(+)

• R-(+)

• R-(-)

Meperidine undergoes which Phase 1 metabolic reaction

• Reduction

• Oxidation

• N - dealkylation

• O - methylation

Naturally occurring morphine has _____ absolute configuration

• 5R,6S,9R,13S,14R

• 5R,6R,8R,13R,14R

• 5R,6S,9R,13S

• 2R,6S,9R,13S,14R

The _____ found in naturally occuring morphine is engaged in a hydrogen bond with a µ-receptor Asn residue

• 14α - OH

• 6β - OH

• 6α - OH

• 14β - OH

The anilidopiperidines are commonly known as _____

• morphinans

• benzomorphans

• Fentanyls

• Morphines