Pathology quizz 2

Of the following histopathologic finding, the one best indicates that a neoplasm is malignant is:

• Pleomorphism

• Atypia

• Invasion

• Increased Nuclear/Cytoplasmic Ratio

• Necrosis

Which of the following is not a feature of stem cells:

• A.Capable of self renewa

• B.Capable of linkage generation

• C. They are the predominant population in a tissue

• D.They belong to the terminal differentiation compartment

• E. Both A and B

All of the following are thought to be related to the capacity for tumor cells to invade except:

• Elaboration of Type IV Collagenase

• Expression of Laminin Receptors

• Mitotic Rate

• Production of Proteases

Grading of tumours depends upon the following except:

• Degree of anaplasia

• Metastatic spread

• . Rate of growth of cells

• . Degree of differentiation

• Number of mitosis

A 45 year old female was found to have an abnormal PAP smear 10 years ago but failed to seek further medical attention (PAP smear is a screening test for cervical cancer She now presents with post coital bleeding and dyspareunia. An exophytic fungating mass is seen on the cervix and a biopsy was taken. The histological finding that will support diagnosis of well differentiated squamous cell carcinoma would be

• absence of necrosis

• presence of Keratin pearls

• presence of Pleomorphism

• presence of desmoplasia

• orderly maturation of squamous cells from the basement membrane

25 yrs old lady who has been working as a radiology technologist for the last 3 years came to outpatient clinic complaining of fatigability. She is worried as her friends told her that she was not well protected in her job and her repeated exposure to radiation will probably cause cancer. What is the mechanism by which radiation damage cells?

• Rupture of the DNA strands

• Alteration of bases

• Destruction of some sugars

• Crosslinking and formation of dimers

• all of the answers are correct

Dysplasia is a known premalignant condition, which of the following is true regarding dysplasia:

• irreversible

• occurs in ulcerative colitis

• may progress into metaplasia

• is associated with invasion of the basement membrane.

• . is usually seen in the uterine endocervix.

70 years old male diagnosed as having a neoplasm in his colon which has been metastasized to different areas of his body, which of the following complications is not considered as non metastatic manifestations of cancer?

• Myopathy

• Polycythaemia

• Venous thrombosis

• Jaundice

• Non bacterial thrombotic endocarditis.

40 yrs old female presented with right breast lump, this lump is 8x4 cm in diameter, attached to the skin and underlying tissue. There are 2 palpable lymph nodes on the right axilla. CT scan was done and revealed no other lymph node groups or any distant lesion. The staging of this breast cancer is:

• T4N1M1

• T4N2M1

• T4N2MO

• T4N1MO

• T4NOMO

A 70 yrs old man presented to the ER with retention of urine, he had a history of abnormal flow of the urine for the last 3 months but he never sought medical advice. the doctor in charge though he might have a prostate cancer, which of the following tumor markers he is going to do?

• Beta-HCG

• Alfa -Feto protein

• CEA

• PSA

• CA 128