Hema 2 4th Lecture Quiz (Hema 2 Section D)

Hemostasis is most effective in which of the following situation?

• 2 inches wound in the left thigh of a 17 year old female

• 2 inches wound in the scalp of an 80 year old male

• 2 inches wound in the left thigh of an 80 year old female

• 2 inches wound in the forehead of 17 year-old man

Which of the following is secreted by endothelial cells that promote coagulation?

• Fibrinogen

• ADP

• Von Willebrand factor

• Platelet factor 4

The following statements are TRUE about fibrinolysis EXCEPT:

• Protein C and S are substances that inactive tissue plaminogen activator inhibitors (tPAI)

• Clot lysis is slow because of the fibrin crosslinking the platelets, RBCs and WBCs.

• Lysis will start as soon as the clot is formed.

• Fibrin split products are the products released after clot lysis.

Which of the following platelet produced substances promote coagulation?

• Thrombospondin

• Fibrinogen

• ADP

• Platelet factor 4

The following are the roles played by the platelets in hemostasis EXCEPT?

• They induced clot retraction, stabilization of clot and lysis.

• They adhere to injured vessels

• They promote coagulation on their phospholipid surface

• They aggregate at the injury site

Which of the following statements is TRUE about the vascular component of the hemostatis?

• The endothelial cells in blood vessels secrete substances -promote coagulation as Prostacyclin & adenosine.

• Thrombomodulin is a substance secreted by endothelial cells that is required for platelet adhesion.

• The intact endothelium of a vessel does not promote coagulation

• The collagen exposure of damaged endothelium initiates the extrinsic coagulation pathway.

The proteolytic enzyme that is primary responsible for fibrinolysis.

• Tissue plasminogen activator

• Thrombin

• Plasmin

• Protein C

Thrombus formation is most commonly seen in which of the following?

• Clotting factor deficiency

• Pancreatic cancer

• Uremia

• Chronic alcoholism

What step is platelet adhesion to exposed sub endothelial connective tissue in the hemostasis after vessel injury?

• First

• Second

• Third

• Fourth

• Fifth

Which of the following is/are not needed in the immediate activation of prothrombin?

• A.Factor V

• B.Factor X

• C.Factor IX

• D.A and C only