GI FARMAKOLÓGIA

Most effective drugs for the treatment of chemotherapy induced vomiting:

• Dexamethasone

• Fosaprepitant

• Ondansetron

• Cholestyramine

Vomiting pathomechanism - which is true?

• seasickness/ kinetosis - vestibular nuclei

• Chemotherapy - vestibular nuclei

• Anticipatory vomiting - Gastrointestinal afferents

• Chemoreceptor trigger zone - inside the blood brain barrier

Pharmacology of constripation - which pair is FALSE?

• Lactulose - hepatic encephalopathy

• Paraffin oil - ozmotic laxative

• Senna - side effect: dark stool and urine

• Purgative effect - pasty stool

Vomiting, diarrhea - which pair is true?

• IBD - acute diarrhea

• EHEC - obstipants are forbidden to be given

• Norovirus - chronic gastroenteritis

• EHEC - antibiotics are forbidden to be given

Which pair is true?

• Bizmuth salt - absorbent

• Activated charcoal - adstringent

• Methylnaltrexone - obstipant

• Loperamide - obstipant

Which pair is FALSE?

• Ursodeoxycholic acid - treatment of hypercholesterolemia

• Cholesevelam - treatment of bile acid induced diarrhea

• Propranolol - prophylaxis for bleeding varices

• Silymarin - treatment for acute toxic liver injury

Prokinetic drug:

• Neostigmine

• Drotaverine

• Loperamide

• Atropine

Contraindicated in pregnancy:

• Propranolol

• Paraffin oil

• Lactulose

• Castor oil