DRUGS ACTING ON THE NERVOUS SYSTEM

Its peripheral effects are mediated through the release of

catecholamines. Large doses can induce hallucinations, violent behavior, and

psychoses in humans.

• Ephedrine

• Methamphetamine

• Amphetamine

• Phenylpropanolamine

Refers to the acetylcholine-like effect without distinction as to anatomic site

of action

• Cholinergic

• Acetylcholine

• Nicotinic stimulation

• Parasympathomimetic

These effects are mediated at the autonomic ganglia, adrenal medulla,

and motor-end plate.

• Pharmacological effects

• Muscarinic stimulation

• Treatment of OP poisoning

• Nicotinic stimulation

Having no action on nicotinic receptors, it produces typical muscarinic effects

such as increased glandular secretion, bradycardia, and hypotension.

• Methacholine

• Muscarine

• Pilocarpine

• Arecoline

It binds to the esteratic site of cholinesterase, inhibiting it for a few hours. The

bond spontaneously breaks off to leave a fully active enzyme.

• Physostigmine

• Carbaryl

• Edrophonium

• Neostigmine

A natural congener of atropine, has more CNS effects than atropine.

It has been used in women to produce “twilight sleep” during childbirth. It is not used

in animals.

• Scopolamine,

• Hyoscine

• Homatropine

• Eucatropine

Adrenergic or sympathomimetic drugs are amine substances that cause physiologic

responses similar to those evoked by the endogenous adrenergic mediators,

epinephrine and norepinephrine upon stimulation of adrenoceptors.

• TRUE

• FALSE

Potent agonist of all adrenoceptors

• Norepinephrine

• Epinephrine

• Dopamine

• Isoproterenol

Decreases blood pressure by decreasing peripheral resistance, primarily

in skeletal muscle

• NOREPINEPHRINE

• DOPAMINE

• EPINEPHRINE

• ISOPROTERENOL

Racemic mixture of D- and L- hyoscyamine, the prototype of

parasympatholytic drugs. They are the active poisons in deadly nightshade

(Atropa belladonna), Jimson weed (Datura stramonium) and henbane

(Hyocayamus niger)

• Eucatropine

• Atropine

• Scopolamine,

• Hyoscine