Microbiology Chp 10 Review

Which of the following people developed the antibiotic Penicillin?

• Wilhelm ron Roentgen

• Francis Crick

• Sir Alexander Fleming

• Joseph Lister

Who discovered arsenic compounds that killed microbes (Syphilis) without harming people

• Paul Ehrlich

• Gerhard Domagk

• Sir Alexander Fleming

• Robert Koch

Who discovered sulfanilamide (the first antibiotic widely available to general public)?

• Paul Ehrlich

• Gerhard Domagk

• Sir Alexander Fleming

• Robert Koch

What drug is structurally similar to PABA and inhibits folic acid synthesis by inhibiting the conversion of PABA to form nucleic acids?

• AZT

• Valaciclovir

• Tetracycline

• Sulfanilamide

What drug(s) inhibit nucleic acid synthesis?

• Beta-lactams

• Valaciclovir and AZT

• Tetracycline

• Sulfanilamide

What drug(s) inhibits the synthesis of bacterial walls?

• Beta-lactams

• Valaciclovir and AZT

• Tetracycline

• Sulfanilamide

Selective toxicity means that

• the drug kills only a small subset of microbes

• the drug kills bacteria but not helminths

• the drug kills microbes but is not harmful to the host

• the drug can be used at a wide range of concentrations

Vancomycin and cycloserine

• disrupt mycolic acid formation in mycobaterial species

• blocks transport of NAG and NAM from cytoplasm

• interfere with particular bridges that link NAM subunits (blocks the alanine bridge)

• synthesizes glucan

Isoniazid and ethambutol

• disrupt mycolic acid formation in mycobaterial species

• blocks transport of NAG and NAM from cytoplasm

• interfere with particular bridges that link NAM subunits (blocks the alanine bridge)

• synthesizes glucan

Qualities of semisynthetic derivatives of beta-lactams except

• More stable in basic enviroment

• more readily absorbed

• More effective than unmodified natural antibiotics

• less susceptible to deactivation