CML & PV Hema

A peripheral blood film that shows increased neutrophils, basophils, eosinophils, and platelets is highly suggestive of:

• AML

• CML

• MDS

• Multiple myeloma

Which of the following chromosome abnormalities is associated with CML?

• t (15;17)

• t (8;14)

• t (9;22)

• Monosomy 7

A patient has a platelet count of 700 X 109 /L with abnormalities in the size, shape, and granularity of platelets; a WBC count of 12 X 109 /L; and hemoglobin of 11 g/dL. The Philadelphia chromosome is not present. The most likely diagnosis is

• PV

• ET

• CML

• Leukemoid reaction

The peripheral blood in PV typically manifests:

• Erythrocytosis only

• Erythrocytosis and thrombocytopenia

• Erythrocytosis, thrombocytosis, and granulocytosis

• Anemia and thrmbocytopenia

The most common mutation found in patients with primary PV is:

• BCR - ABL1

• Philadelphia chromosome

• JAK2 V617F

• t (15;17)

A patient in whom CML has previously been diagnosed has circulating blasts and promyelocytes that total 30% of leukocytes. The disease is considered to be in what phase?

• Chronic stable phase

• Accelerated phase

• Transformation to acute leukemia

• Temporary remission

A patient has a WBC count 30 X 10^9 /L and the following WBC differential count:

Segmented neutrophils - 38%

Bands - 17%

Metamyelocytes - 7%

Promyelocytes - 10%

Eosinophils - 3%

Basophils - 5%

Which of the following test results would be helpful in determining whether the patient has CML?

• Nitroblue tetrazolium reduction product increased

• Myeloperoxidase increased

• Periodic acid - Schiff staining decreased

• FISH positive for BCR-ABLI fusion

Complications of ET include all of the following except:

• Thrombosis

• Hemorrhage

• Seizures

• Infections

Which of the following patterns is characteristic of the peripheral blood in patients with PMF?

• Teardrop-shaped erythrocytes, nucleated RBCs, immature granulocytes

• Abnormal platelets only

• Hypochromic erythrocytes, immature granulocytes, and normal platelets

• Spherocytes, immature granulocytes, and increased numbers of platelets

this mutation is observed in 50% to 60% of patients with ET and PMF and contributes to the pathogenesis of the disorders

• JAK2 V617F

• PCM1-JAK2

• T315I

• PDGFRA