Toxicity

The third step in the development of toxicity is covalent binding to target molecule

• True

• False

Mitochondrial damage with ATP depletion may lead to necrosis.

• True

• False

DNA repair principles in order is Recognition -> Removal -> Ligation -> Repair

• True

• False

Mutagens cause DNA damage by affecting the coding sequences of critical genes.

• True

• False

Cellular damage caused by epigenetic mechanisms is non-genotoxic.

• True

• False

If an initiating carcinogen mutates the DNA, the cell must progress to cancer.

• True

• False

Inhibition of acetycholinesterase by organophosphates will cause overstimulation of cholinergic receptors.

• True

• False

In OPs poisoning management, Atropine facilitates dephosphorylation of the AChE, thus restoring its catalytic site to its function.

• True

• False

Lead inhibit the ferrochelatase enzyme which results in accumulation of protophorphyrin IX - as the erythrocytes containing protoporphyrin IX circulate, zinc is chelated at the site usually occupied by iron.

• True

• False

Antivenom therapy works by the concept of antibody binding to protein.

• True

• False